CUL5

Gene Symbol	CUL5
Entrez Gene	8065
Alt Symbol	VACM-1, VACM1
Species	Human
Gene Type	protein-coding
Description	cullin 5
Other Description	CUL-5|Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)|Vasopressin-activated calcium-mobilizing receptor-1|cullin-5|vasopressin-activated calcium-mobilizing receptor 1
Swissprots	A8K960 Q93034 Q9BZC6 O14766
Accessions	EAW67101 EAW67102 Q93034 AA099369 AA403092 AA471067 AF017061 AAB70253 AF327710 AAK07472 AK125294 AK292575 BAF85264 BC017838 BC037203 BC063306 AAH63306 H01402 X81882 CAA57465 XM_005271682 XP_005271739 XM_011543012 XP_011541314 XM_011543013 XP_011541315 NM_003478 NP_003469
Function	Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cullin 5 protein fragment - ab159938 from Abcam Category Protein Source Wheat germ Species Human

CUL5 / Cullin-5 Antibody Blocking Peptide - LS-E9069 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cullin 5 Protein - H00008065-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CUL5-Antibody-C-term-Blocking-Peptide - BP7577b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cullin 5 Blocking Peptide - 33R-9706 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cullin-5 - H00008065-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cullin-5 - H00008065-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CUL5 fusion protein - ag5168 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CUL5 fusion protein - Ag5453 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human CUL5/RNF7 - CUL5-149H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human Cullin-5(CUL5) - CSB-YP835890HU CSB-EP835890HU CSB-BP835890HU CSB-MP835890HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Cullin-5 - TP309273 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Cullin 5 Recombinant Protein Antigen - NBP1-86868PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CUL5-Antibody-Center-Blocking-Peptide - BP7577c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CUL5 Peptide, Human - M34GP03843H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cullin-5 (CUL5), Recombinant Protein - MBS1407753 from MyBioSource Category Protein Prices $1,595.00, $1,595.00, $1,825.00, $1,825.00, $2,760.00, $2,760.00, $3,200.00, $3,200.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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