| Gene Symbol |
CUL5
|
| Entrez Gene |
8065
|
| Alt Symbol |
VACM-1, VACM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cullin 5
|
| Other Description |
CUL-5|Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)|Vasopressin-activated calcium-mobilizing receptor-1|cullin-5|vasopressin-activated calcium-mobilizing receptor 1
|
| Swissprots |
A8K960 Q93034 Q9BZC6 O14766
|
| Accessions |
EAW67101 EAW67102 Q93034 AA099369 AA403092 AA471067 AF017061 AAB70253 AF327710 AAK07472 AK125294 AK292575 BAF85264 BC017838 BC037203 BC063306 AAH63306 H01402 X81882 CAA57465 XM_005271682 XP_005271739 XM_011543012 XP_011541314 XM_011543013 XP_011541315 NM_003478 NP_003469
|
| Function |
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: Cullin 5 Overexpression Lysate (Adult Normal) [NBL1-09611] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cullin 5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14191_Cullin%25205%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09611-img0002.jpg)