TRIM37

Gene Symbol TRIM37
Entrez Gene 4591
Alt Symbol MUL, POB1, TEF3
Species Human
Gene Type protein-coding
Description tripartite motif containing 37
Other Description E3 ubiquitin-protein ligase TRIM37|RING-B-box-coiled-coil protein|mulibrey nanism protein|tripartite motif-containing protein 37
Swissprots Q8IYF7 Q8WYF7 A8K0V9 B4DGZ3 A8K8U4 Q7Z3E6 F8WEE6 O94972 A8MZ79
Accessions EAW94424 EAW94425 EAW94426 EAW94427 O94972 AB020705 BAA74921 AF213365 AAL36460 AI307801 AK022701 BAG51105 AK025648 AK289674 BAF82363 AK292459 BAF85148 AK294850 BAG57954 BC036012 AAH36012 BG722700 BQ447834 BX537955 CAD97922 CN388771 DC351295 XM_005257385 XP_005257442 XM_005257387 XP_005257444 XM_005257389 XP_005257446 XM_005257390 XP_005257447 XM_011524831 XP_011523133 XM_011524832 XP_011523134 XM_011524833 XP_011523135 XM_011524834 XP_011523136 XM_011524835 XP_011523137 XM_011524836 XP_011523138 XM_011524837 XP_011523139 NM_001005207 NP_001005207 NM_015294 NP_056109
Function E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:15885686}. Peroxisome {ECO:0000269|PubMed:11938494}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269|PubMed:15885686}.
Tissue Specificity Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976). {ECO:0000269|PubMed:10888877, ECO:0000269|PubMed:16310976}.
Top Pathways Ubiquitin mediated proteolysis

TRIM37 (C-15) - sc-49548 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRIM37 (C-15): sc-49548. Western blot analysis of TRIM37 expression in Raji (A), HeLa (B) and A-431 (C) whole cell lysates.

TRIM37 (D-20) - sc-49549 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRIM37 (D-20): sc-49549. Western blot analysis of TRIM37 expression in Hep G2 whole cell lysate.

TRIM37 (H-300) - sc-368559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRIM37 (H-300): sc-368559. Western blot analysis of TRIM37 expression in Raji (A), HeLa (B), RT-4 (C), A-431 (D) and Hep G2 (E) whole cell lysates.

Anti-TRIM37 antibody - ab95997 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TRIM37 antibody (ab95997) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-TRIM37 antibody - ab13619 from Abcam

Prices $242.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TRIM37 antibody - C-terminal - ab171633 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TRIM37 antibody - C-terminal (ab171633) at 1/100 dilution + HeLa cell line lysate at 35 µgSecondaryAnti-rabbit HRP conjugated antibody at 1/10000 dilutiondeveloped using the ECL technique

Anti-TRIM37 antibody - N-terminal - ab157247 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRIM37 antibody - N-terminal (ab157247) at 1/1000 dilutionLane 1 : HepG2 total cell extractLane 2 : Jurkat total cell extract

Anti-TRIM37 / TEF3 Antibody (aa918-930) - LS-C55625 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa850-900) - LS-C76562 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa914-964) - LS-C76563 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa936-964, APC) - LS-C207807 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa936-964, AP) - LS-C207808 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa936-964, Biotin) - LS-C207809 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa936-964, FITC) - LS-C207811 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa936-964, Azide-free, HRP) - LS-C207812 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa936-964, PE) - LS-C207813 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa850-900) - LS-C287995 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa914-964) - LS-C287996 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (aa935-964) - LS-C325947 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM37 / TEF3 Antibody (C-Terminus) - LS-C110732 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRIM37 antibody LS-C110732 Western blot of PANC1 cell lysate.

Anti-TRIM37 / TEF3 Antibody (clone 2D11) - LS-C197720 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D11
Detection limit for recombinant GST tagged TRIM37 is approximately 0.3 ng/ml as a capture antibody.

Anti-TRIM37 / TEF3 Antibody (aa936-964) - LS-C157273 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TRIM37 Antibody western blot of HeLa cell line lysates (35 ug/lane). The TRIM37 antibody detected the TRIM37 protein (arrow).

Anti-TRIM37 / TEF3 Antibody (aa902-964) - LS-C185780 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded U87 xenograft using TRIM37 antibody at 1:500 dilution.

TRIM37 Antibody - NBP1-92529 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TRIM37 Antibody [NBP1-92529] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-598

TRIM37 Antibody - NB100-59820 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: TRIM37 Antibody [NB100-59820] - Detection of Human TRIM37 on HeLa whole cell lysate using NB100-59820. TRIM37 was also immunoprecipitated by rabbit anti-TRIM37 antibody NB100-59821. For blotting immunoprecipitated TRIM37 NB100-59821 was used at 1.0 ug/ml.
Search more