| Gene Symbol |
TRIM37
|
| Entrez Gene |
4591
|
| Alt Symbol |
MUL, POB1, TEF3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 37
|
| Other Description |
E3 ubiquitin-protein ligase TRIM37|RING-B-box-coiled-coil protein|mulibrey nanism protein|tripartite motif-containing protein 37
|
| Swissprots |
Q8IYF7 Q8WYF7 A8K0V9 B4DGZ3 A8K8U4 Q7Z3E6 F8WEE6 O94972 A8MZ79
|
| Accessions |
EAW94424 EAW94425 EAW94426 EAW94427 O94972 AB020705 BAA74921 AF213365 AAL36460 AI307801 AK022701 BAG51105 AK025648 AK289674 BAF82363 AK292459 BAF85148 AK294850 BAG57954 BC036012 AAH36012 BG722700 BQ447834 BX537955 CAD97922 CN388771 DC351295 XM_005257385 XP_005257442 XM_005257387 XP_005257444 XM_005257389 XP_005257446 XM_005257390 XP_005257447 XM_011524831 XP_011523133 XM_011524832 XP_011523134 XM_011524833 XP_011523135 XM_011524834 XP_011523136 XM_011524835 XP_011523137 XM_011524836 XP_011523138 XM_011524837 XP_011523139 NM_001005207 NP_001005207 NM_015294 NP_056109
|
| Function |
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:15885686}. Peroxisome {ECO:0000269|PubMed:11938494}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269|PubMed:15885686}.
|
| Tissue Specificity |
Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976). {ECO:0000269|PubMed:10888877, ECO:0000269|PubMed:16310976}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|