TRIM37

Gene Symbol TRIM37
Entrez Gene 4591
Alt Symbol MUL, POB1, TEF3
Species Human
Gene Type protein-coding
Description tripartite motif containing 37
Other Description E3 ubiquitin-protein ligase TRIM37|RING-B-box-coiled-coil protein|mulibrey nanism protein|tripartite motif-containing protein 37
Swissprots Q8IYF7 Q8WYF7 A8K0V9 B4DGZ3 A8K8U4 Q7Z3E6 F8WEE6 O94972 A8MZ79
Accessions EAW94424 EAW94425 EAW94426 EAW94427 O94972 AB020705 BAA74921 AF213365 AAL36460 AI307801 AK022701 BAG51105 AK025648 AK289674 BAF82363 AK292459 BAF85148 AK294850 BAG57954 BC036012 AAH36012 BG722700 BQ447834 BX537955 CAD97922 CN388771 DC351295 XM_005257385 XP_005257442 XM_005257387 XP_005257444 XM_005257389 XP_005257446 XM_005257390 XP_005257447 XM_011524831 XP_011523133 XM_011524832 XP_011523134 XM_011524833 XP_011523135 XM_011524834 XP_011523136 XM_011524835 XP_011523137 XM_011524836 XP_011523138 XM_011524837 XP_011523139 NM_001005207 NP_001005207 NM_015294 NP_056109
Function E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:15885686}. Peroxisome {ECO:0000269|PubMed:11938494}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269|PubMed:15885686}.
Tissue Specificity Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976). {ECO:0000269|PubMed:10888877, ECO:0000269|PubMed:16310976}.
Top Pathways Ubiquitin mediated proteolysis

TRIM37 CRISPR/Cas9 KO Plasmid (h) - sc-407390 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM37 HDR Plasmid (h) - sc-407390-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM37 Double Nickase Plasmid (h) - sc-407390-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM37 Double Nickase Plasmid (h2) - sc-407390-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM37 CRISPR Activation Plasmid (h) - sc-407390-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM37 CRISPR Activation Plasmid (h2) - sc-407390-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM37 Lentiviral Activation Particles (h) - sc-407390-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM37 Lentiviral Activation Particles (h2) - sc-407390-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRIM37 siRNA (h) - sc-61716 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIM37 shRNA Plasmid (h) - sc-61716-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIM37 shRNA (h) Lentiviral Particles - sc-61716-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRIM37 RNAi - H00004591-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TRIM37 RNAi - H00004591-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU052971 from Sigma-Aldrich

Category siRNA

MISSION® esiRNA - EHU044581 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21975 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21975 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08467 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08467

TRIM37 siRNA (Human) - CRH3024 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRIM37 - MBS8211376 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TRIM37 (NM_015294.3) - SHH434676 from Creative biogene

Category siRNA
Species Reactivities Human

Human TRIM37 siRNA - orb263526 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRIM37 shRNA Plasmid (Human) - CHH3024 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TRIM37 miRNA 3'UTR clone - MiUTR3H-07347 from Creative biogene

Species Reactivities Human

TRIM37 miRNA 3'UTR clone - MiUTR3H-07348 from Creative biogene

Species Reactivities Human
Search more