TRIM37

Gene Symbol	TRIM37
Entrez Gene	4591
Alt Symbol	MUL, POB1, TEF3
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 37
Other Description	E3 ubiquitin-protein ligase TRIM37|RING-B-box-coiled-coil protein|mulibrey nanism protein|tripartite motif-containing protein 37
Swissprots	Q8IYF7 Q8WYF7 A8K0V9 B4DGZ3 A8K8U4 Q7Z3E6 F8WEE6 O94972 A8MZ79
Accessions	EAW94424 EAW94425 EAW94426 EAW94427 O94972 AB020705 BAA74921 AF213365 AAL36460 AI307801 AK022701 BAG51105 AK025648 AK289674 BAF82363 AK292459 BAF85148 AK294850 BAG57954 BC036012 AAH36012 BG722700 BQ447834 BX537955 CAD97922 CN388771 DC351295 XM_005257385 XP_005257442 XM_005257387 XP_005257444 XM_005257389 XP_005257446 XM_005257390 XP_005257447 XM_011524831 XP_011523133 XM_011524832 XP_011523134 XM_011524833 XP_011523135 XM_011524834 XP_011523136 XM_011524835 XP_011523137 XM_011524836 XP_011523138 XM_011524837 XP_011523139 NM_001005207 NP_001005207 NM_015294 NP_056109
Function	E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:15885686}. Peroxisome {ECO:0000269|PubMed:11938494}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269|PubMed:15885686}.
Tissue Specificity	Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976). {ECO:0000269|PubMed:10888877, ECO:0000269|PubMed:16310976}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRIM37 full length protein - ab167952 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human TRIM37 peptide - ab23224 from Abcam Category Peptide Species Human

Human TRIM37 protein fragment - ab116888 from Abcam Category Protein Source Wheat germ Species Human

TRIM37 / TEF3 Antibody Blocking Peptide - LS-E2328 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM37 / TEF3 Antibody Blocking Peptide - LS-E25428 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM37 / TEF3 Antibody Blocking Peptide - LS-E15811 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRIM37 Protein - H00004591-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRIM37-Antibody-C-term-Blocking-peptide - BP13288b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRIM37 blocking peptide - GTX13619-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

TRIM37 Blocking Peptide - 33R-3441 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRIM37 Peptide - AC21-0256-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRIM37 - H00004591-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRIM37 - H00004591-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRIM37 Peptide - 46-524P from ProSci Category Peptide

TRIM37 fusion protein - ag3690 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TRIM37 - TRIM37-31610TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human TRIM37, GST-tagged - TRIM37-199H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

TRIM37 protein-GST fusion - 009-001-U21 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

TRIM37 protein-GST fusion - 009-001-U21S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human E3 ubiquitin-protein ligase TRIM37(TRIM37) ,partial - CSB-YP024474HU CSB-EP024474HU CSB-BP024474HU CSB-MP024474HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRIM37, Peptide - MBS426010 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Bovine

TRIM37 Recombinant Protein Antigen - NBP1-92529PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRIM37 Peptide, Human - M34GP16589H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase TRIM37 (TRIM37), partial, Recombinant Protein - MBS1186091 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

TRIM37 Immunizing peptide - orb17715 from Biorbyt Category Peptide

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