TRIM37

Gene Symbol	TRIM37
Entrez Gene	4591
Alt Symbol	MUL, POB1, TEF3
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 37
Other Description	E3 ubiquitin-protein ligase TRIM37|RING-B-box-coiled-coil protein|mulibrey nanism protein|tripartite motif-containing protein 37
Swissprots	Q8IYF7 Q8WYF7 A8K0V9 B4DGZ3 A8K8U4 Q7Z3E6 F8WEE6 O94972 A8MZ79
Accessions	EAW94424 EAW94425 EAW94426 EAW94427 O94972 AB020705 BAA74921 AF213365 AAL36460 AI307801 AK022701 BAG51105 AK025648 AK289674 BAF82363 AK292459 BAF85148 AK294850 BAG57954 BC036012 AAH36012 BG722700 BQ447834 BX537955 CAD97922 CN388771 DC351295 XM_005257385 XP_005257442 XM_005257387 XP_005257444 XM_005257389 XP_005257446 XM_005257390 XP_005257447 XM_011524831 XP_011523133 XM_011524832 XP_011523134 XM_011524833 XP_011523135 XM_011524834 XP_011523136 XM_011524835 XP_011523137 XM_011524836 XP_011523138 XM_011524837 XP_011523139 NM_001005207 NP_001005207 NM_015294 NP_056109
Function	E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24317724, ECO:0000269|PubMed:25470042}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:15885686}. Peroxisome {ECO:0000269|PubMed:11938494}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269|PubMed:15885686}.
Tissue Specificity	Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976). {ECO:0000269|PubMed:10888877, ECO:0000269|PubMed:16310976}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRIM37 overexpression lysate - LY423800 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TRIM37 overexpression lysate - LY425127 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRIM37 293 Cell Lysate - 407008 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TRIM37 Overexpression Lysate (Native) - NBL1-17293 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TRIM37 Overexpression Lysate (Native) - NBP2-08877 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TRIM37 Overexpression Lysate (Native) - NBP2-09094 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

TRIM37 Over-expression Lysate Product - GWB-763274 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human TRIM37 Knockdown Stable Cell Line - CSC-DC016589 from Creative biogene Category Cell Line Species Human

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