| Gene Symbol |
SOX7
|
| Entrez Gene |
83595
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SRY (sex determining region Y)-box 7
|
| Other Description |
transcription factor SOX-7
|
| Swissprots |
Q9BT81 B4DKV0 Q53YD0
|
| Accessions |
Q9BT81 AJ409320 CAC84226 AK055556 BAB70955 AK223574 BAD97294 BC004299 BC071947 AAH71947 BE671627 BG740632 BT006693 AAP35339 BU187815 HY089489 NM_031439 NP_113627
|
| Function |
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}. Cytoplasm {ECO:0000269|PubMed:18819930}.
|
| Tissue Specificity |
Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. {ECO:0000269|PubMed:11691915, ECO:0000269|PubMed:18819930}.
|
![Western Blot: SOX7 Overexpression Lysate (Adult Normal) [NBL1-16355] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SOX7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4842_SOX7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16355-img0002.jpg)