| Gene Symbol | FBXW7 |
|---|---|
| Entrez Gene | 55294 |
| Alt Symbol | AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
| Other Description | F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)|F-box protein FBW7|F-box protein FBX30|F-box protein SEL-10|F-box/WD repeat-containing protein 7|archipelago|homolog of C elegans sel-10 |
| Swissprots | Q96RI2 Q68DR0 Q9NUX6 Q96LE0 Q969H0 Q96A16 B7ZLP9 |
| Accessions | AFD64626 AFD64627 BAF73721 EAX04977 EAX04978 EAX04979 Q969H0 AB209725 BAD92962 AF383178 AAK60269 AF411971 AAL06290 AF411972 AAL06291 AI598129 AK001933 BAA91986 AK131383 AK223449 BAD97169 AK294568 BAH11814 AK299722 BAH13109 AK315142 AW965611 AY008274 AAG16640 AY033553 AAK57547 AY049984 AAL07271 BC014503 BC037320 AAH37320 BC059373 BC117244 AAI17245 BC117246 AAI17247 BC143944 AAI43945 BF514288 BI496455 BX498391 CR749305 CAH18160 DA321362 HQ258348 ADR83102 HQ873864 AEK48270 HQ873865 AEK48271 HQ873866 AEK48272 HQ873867 AEK48273 HQ873868 AEK48274 HQ873869 AEK48275 HQ873870 AEK48276 W39194 XM_011532083 XP_011530385 XM_011532084 XP_011530386 XM_011532085 XP_011530387 XM_011532086 XP_011530388 XM_011532087 XP_011530389 XM_011532088 XP_011530390 NM_001013415 NP_001013433 NM_001257069 NP_001243998 NM_018315 NP_060785 NM_033632 NP_361014 |
| Function | Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). {ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, EC |
| Subcellular Location | Isoform 3: Nucleus, nucleolus {ECO:0000269|PubMed:17558397}. |
| Tissue Specificity | Isoform 1 is widely expressed. Isoform 3 is expressed in brain. {ECO:0000269|PubMed:12354302}. |
| Top Pathways | Ubiquitin mediated proteolysis |
F-box/WD repeat-containing protein 7 (FBXW7), Human, ELISA Kit - E01F0338 from ARP American Research Products
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F box/WD repeat containing protein 7 (FBXW7), ELISA Kit - MBS7241547 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7228940 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7240975 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7238416 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7232321 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7204170 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7205733 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7229333 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7251110 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7218128 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7224814 from MyBioSource
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F-box/WD repeat-containing protein 7 (FBXW7), ELISA Kit - MBS7219451 from MyBioSource
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Human FBXW7 ELISA Kit - E014005 from Biobool
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anti-FBXW7 antibody [SP237] - ARG53014 from Arigo Biolaboratories
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anti-FBXW7 antibody [SP237] (Ready-to-Use) - ARG53015 from Arigo Biolaboratories
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