FBXW7

Gene Symbol	FBXW7
Entrez Gene	55294
Alt Symbol	AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Species	Human
Gene Type	protein-coding
Description	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Other Description	F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)|F-box protein FBW7|F-box protein FBX30|F-box protein SEL-10|F-box/WD repeat-containing protein 7|archipelago|homolog of C elegans sel-10
Swissprots	Q96RI2 Q68DR0 Q9NUX6 Q96LE0 Q969H0 Q96A16 B7ZLP9
Accessions	AFD64626 AFD64627 BAF73721 EAX04977 EAX04978 EAX04979 Q969H0 AB209725 BAD92962 AF383178 AAK60269 AF411971 AAL06290 AF411972 AAL06291 AI598129 AK001933 BAA91986 AK131383 AK223449 BAD97169 AK294568 BAH11814 AK299722 BAH13109 AK315142 AW965611 AY008274 AAG16640 AY033553 AAK57547 AY049984 AAL07271 BC014503 BC037320 AAH37320 BC059373 BC117244 AAI17245 BC117246 AAI17247 BC143944 AAI43945 BF514288 BI496455 BX498391 CR749305 CAH18160 DA321362 HQ258348 ADR83102 HQ873864 AEK48270 HQ873865 AEK48271 HQ873866 AEK48272 HQ873867 AEK48273 HQ873868 AEK48274 HQ873869 AEK48275 HQ873870 AEK48276 W39194 XM_011532083 XP_011530385 XM_011532084 XP_011530386 XM_011532085 XP_011530387 XM_011532086 XP_011530388 XM_011532087 XP_011530389 XM_011532088 XP_011530390 NM_001013415 NP_001013433 NM_001257069 NP_001243998 NM_018315 NP_060785 NM_033632 NP_361014
Function	Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). {ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, EC
Subcellular Location	Isoform 3: Nucleus, nucleolus {ECO:0000269|PubMed:17558397}.
Tissue Specificity	Isoform 1 is widely expressed. Isoform 3 is expressed in brain. {ECO:0000269|PubMed:12354302}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FBXW7 293T Cell Transient Overexpression Lysate(Denatured) - H00055294-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

FBXW7 overexpression lysate - LY403254 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

FBXW7 overexpression lysate - LY413158 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

FBXW7 overexpression lysate - LY422971 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

FBXW7 overexpression lysate - LY425348 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

FBXW7 293 Cell Lysate - 406373 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

FBXW7 293 Cell Lysate - 402826 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

FBXW7/Cdc4 Overexpression Lysate (Native) - NBL1-10647 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

FBXW7/Cdc4 Overexpression Lysate (Native) - NBL1-10648 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

FBXW7 Over-expression Lysate Product - GWB-856163 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

FBXW7 Over-expression Lysate Product - GWB-734490 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

FBXW7/Cdc4 Overexpression Lysate (Native) - NBP2-11011 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

FBXW7/Cdc4 Overexpression Lysate (Native) - NBP2-11238 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FBXW7/Cdc4 Overexpression Lysate (Denatured) - H00055294-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

FBXW7/Cdc4 Overexpression Lysate (Denatured) - H00055294-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

FBXW7-knockout Cell lysate - LC810367 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human FBXW7 Knockdown Stable Cell Line - CSC-DC005627 from Creative biogene Category Cell Line Species Human

Human FBXW7 Knockout Cell Line-HEK293T - CSC-RT0661 from Creative biogene Category Cell Line Species Human

FBXW7 KO Cell Lysate-HEK293T - CLKO-0167 from Creative biogene Category Cell Lysate

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