FBXW7

Gene Symbol	FBXW7
Entrez Gene	55294
Alt Symbol	AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Species	Human
Gene Type	protein-coding
Description	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Other Description	F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)|F-box protein FBW7|F-box protein FBX30|F-box protein SEL-10|F-box/WD repeat-containing protein 7|archipelago|homolog of C elegans sel-10
Swissprots	Q96RI2 Q68DR0 Q9NUX6 Q96LE0 Q969H0 Q96A16 B7ZLP9
Accessions	AFD64626 AFD64627 BAF73721 EAX04977 EAX04978 EAX04979 Q969H0 AB209725 BAD92962 AF383178 AAK60269 AF411971 AAL06290 AF411972 AAL06291 AI598129 AK001933 BAA91986 AK131383 AK223449 BAD97169 AK294568 BAH11814 AK299722 BAH13109 AK315142 AW965611 AY008274 AAG16640 AY033553 AAK57547 AY049984 AAL07271 BC014503 BC037320 AAH37320 BC059373 BC117244 AAI17245 BC117246 AAI17247 BC143944 AAI43945 BF514288 BI496455 BX498391 CR749305 CAH18160 DA321362 HQ258348 ADR83102 HQ873864 AEK48270 HQ873865 AEK48271 HQ873866 AEK48272 HQ873867 AEK48273 HQ873868 AEK48274 HQ873869 AEK48275 HQ873870 AEK48276 W39194 XM_011532083 XP_011530385 XM_011532084 XP_011530386 XM_011532085 XP_011530387 XM_011532086 XP_011530388 XM_011532087 XP_011530389 XM_011532088 XP_011530390 NM_001013415 NP_001013433 NM_001257069 NP_001243998 NM_018315 NP_060785 NM_033632 NP_361014
Function	Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). {ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, EC
Subcellular Location	Isoform 3: Nucleus, nucleolus {ECO:0000269|PubMed:17558397}.
Tissue Specificity	Isoform 1 is widely expressed. Isoform 3 is expressed in brain. {ECO:0000269|PubMed:12354302}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cdc4 / Fbw7 / hSel 10 peptide - ab12311 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Fbxw7 protein fragment - ab163053 from Abcam Category Protein Source Wheat germ Species Human

FBXW7 / FBW7 Antibody Blocking Peptide - LS-E13424 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBXW7 / FBW7 Antibody Blocking Peptide - LS-E17187 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FBXW7/Cdc4 Protein - H00055294-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FBXW7 Blocking Peptide - 33R-5108 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBXW7 - H00055294-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBXW7 - H00055294-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FBXW7 control peptide - AP05288CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Recombinant F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) - RPJ890Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) - RPJ890Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) - RPJ890Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human F-box/WD repeat-containing protein 7(FBXW7) - CSB-YP822163HU CSB-EP822163HU CSB-BP822163HU CSB-MP822163HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBXW7 Peptide (OEEG01153) - OEEG01153 from Aviva Systems Biology Category Peptide Prices $150.00 Sizes 50 µg Source Rabbit Species Human

FBXW7 Protein - abx164202 from Abbexa Category Protein Species Human, Mouse, Rat

FBXW7, Peptide - MBS396427 from MyBioSource Category Peptide Prices $195.00 Sizes 50 µg Source Rabbit Species Human

FBXW7-Blocking-Peptide-N-term - BP21312a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBXW7-Blocking-Peptide-N-term - BP21277a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBXW7 Peptide, Human - M34GP05627H from Creative Peptides Category Peptide Source Synthetic. Species Human

F-Box And WD Repeat Domain Containing Protein 7, Recombinant Protein - MBS2029887 from MyBioSource Category Protein Prices $200.00, $430.00, $665.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

F-Box And WD Repeat Domain Containing Protein 7, Recombinant Protein - MBS2031603 from MyBioSource Category Protein Prices $190.00, $405.00, $625.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

F-box/WD repeat-containing protein 7 (FBXW7), Recombinant Protein - MBS1440788 from MyBioSource Category Protein Prices $1,515.00, $1,515.00, $1,740.00, $1,740.00, $2,595.00, $2,595.00, $3,035.00, $3,035.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human F-box/WD repeat-containing protein 7(FBXW7) - CSB-CF822163HU from Cusabio Category Protein Source in vitro E.coli expression system Species Human

FBXW7 Recombinant Protein (OPCD03137) - OPCD03137 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant Human F-box/WD repeat-containing protein 7(FBXW7) - AP74500 from Signalway Antibody Category Protein Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

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