FBXW7
| Gene Symbol | FBXW7 |
|---|---|
| Entrez Gene | 55294 |
| Alt Symbol | AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
| Other Description | F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)|F-box protein FBW7|F-box protein FBX30|F-box protein SEL-10|F-box/WD repeat-containing protein 7|archipelago|homolog of C elegans sel-10 |
| Swissprots | Q96RI2 Q68DR0 Q9NUX6 Q96LE0 Q969H0 Q96A16 B7ZLP9 |
| Accessions | AFD64626 AFD64627 BAF73721 EAX04977 EAX04978 EAX04979 Q969H0 AB209725 BAD92962 AF383178 AAK60269 AF411971 AAL06290 AF411972 AAL06291 AI598129 AK001933 BAA91986 AK131383 AK223449 BAD97169 AK294568 BAH11814 AK299722 BAH13109 AK315142 AW965611 AY008274 AAG16640 AY033553 AAK57547 AY049984 AAL07271 BC014503 BC037320 AAH37320 BC059373 BC117244 AAI17245 BC117246 AAI17247 BC143944 AAI43945 BF514288 BI496455 BX498391 CR749305 CAH18160 DA321362 HQ258348 ADR83102 HQ873864 AEK48270 HQ873865 AEK48271 HQ873866 AEK48272 HQ873867 AEK48273 HQ873868 AEK48274 HQ873869 AEK48275 HQ873870 AEK48276 W39194 XM_011532083 XP_011530385 XM_011532084 XP_011530386 XM_011532085 XP_011530387 XM_011532086 XP_011530388 XM_011532087 XP_011530389 XM_011532088 XP_011530390 NM_001013415 NP_001013433 NM_001257069 NP_001243998 NM_018315 NP_060785 NM_033632 NP_361014 |
| Function | Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). {ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, EC |
| Subcellular Location | Isoform 3: Nucleus, nucleolus {ECO:0000269|PubMed:17558397}. |
| Tissue Specificity | Isoform 1 is widely expressed. Isoform 3 is expressed in brain. {ECO:0000269|PubMed:12354302}. |
| Top Pathways | Ubiquitin mediated proteolysis |
Cdc4 CRISPR/Cas9 KO Plasmid (h) - sc-401257 from Santa Cruz Biotechnology
|
||||||||
Cdc4 HDR Plasmid (h) - sc-401257-HDR from Santa Cruz Biotechnology
|
||||||||
Cdc4 Double Nickase Plasmid (h) - sc-401257-NIC from Santa Cruz Biotechnology
|
||||||||
Cdc4 Double Nickase Plasmid (h2) - sc-401257-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Cdc4 CRISPR Activation Plasmid (h) - sc-401257-ACT from Santa Cruz Biotechnology
|
||||||||
Cdc4 CRISPR Activation Plasmid (h2) - sc-401257-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Cdc4 Lentiviral Activation Particles (h) - sc-401257-LAC from Santa Cruz Biotechnology
|
||||||||
Cdc4 Lentiviral Activation Particles (h2) - sc-401257-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Cdc4 siRNA (h) - sc-37547 from Santa Cruz Biotechnology
|
||||||||
Cdc4 shRNA Plasmid (h) - sc-37547-SH from Santa Cruz Biotechnology
|
||||||||
Cdc4 shRNA (h) Lentiviral Particles - sc-37547-V from Santa Cruz Biotechnology
|
||||||||
FBXW7/Cdc4 RNAi - H00055294-R03 from Novus Biologicals
|
||||||||
FBXW7/Cdc4 RNAi - H00055294-R02 from Novus Biologicals
|
||||||||
FBXW7/Cdc4 RNAi - H00055294-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU075951 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1593 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1593 from Sigma-Aldrich
|
||||||||
FBXW7 siRNA (Human) - CRJ0633 from Cohesion Biosciences
|
||||||||
FBXW7 - MBS8222565 from MyBioSource
|
||||||||
shRNA set against Human FBXW7 (NM_033632.3) - SHH293569 from Creative biogene
|
||||||||
shRNA set against Human FBXW7(NM_001013415.1) - SHH053795 from Creative biogene
|
||||||||
shRNA set against Human FBXW7(NM_018315.4) - SHH053803 from Creative biogene
|
||||||||
shRNA set against Human FBXW7(NM_001013415.1) - SHH053821 from Creative biogene
|
||||||||
FBXW7 shRNA Plasmid (Human) - CHJ0633 from Cohesion Biosciences
|
||||||||
FBXW7 miRNA 3'UTR clone - MiUTR1H-03577 from Creative biogene
|