| Gene Symbol |
CES3
|
| Entrez Gene |
23491
|
| Alt Symbol |
ES31
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carboxylesterase 3
|
| Other Description |
carboxylesterase 3 (brain)|esterase 31|liver carboxylesterase 31 homolog
|
| Swissprots |
Q9H6X7 Q7Z6J1 B2Z3W9 F5H242 Q6UWW8
|
| Accessions |
ACD11491 EAW83060 EAW83062 Q6UWW8 AK000105 AK025158 AK025171 AK025389 BAB15123 AK097538 BAC05093 AY358609 AAQ88972 BC053670 AAH53670 DA924627 XM_011522975 XP_011521277 XM_011522976 XP_011521278 NM_001185176 NP_001172105 NM_001185177 NP_001172106 NM_024922 NP_079198 NM_012122
|
| Function |
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000250}.
|
| Tissue Specificity |
Expressed in liver, colon and small intestine. {ECO:0000269|PubMed:14581373, ECO:0000269|PubMed:15100172, ECO:0000269|PubMed:15687373}.
|
![Western Blot: Esterase 31 Overexpression Lysate (Adult Normal) [NBP2-06258] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Esterase 31.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5286_Esterase%252031%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06258-img0001.jpg)