Gene Symbol | CES3 |
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Entrez Gene | 23491 |
Alt Symbol | ES31 |
Species | Human |
Gene Type | protein-coding |
Description | carboxylesterase 3 |
Other Description | carboxylesterase 3 (brain)|esterase 31|liver carboxylesterase 31 homolog |
Swissprots | Q9H6X7 Q7Z6J1 B2Z3W9 F5H242 Q6UWW8 |
Accessions | ACD11491 EAW83060 EAW83062 Q6UWW8 AK000105 AK025158 AK025171 AK025389 BAB15123 AK097538 BAC05093 AY358609 AAQ88972 BC053670 AAH53670 DA924627 XM_011522975 XP_011521277 XM_011522976 XP_011521278 NM_001185176 NP_001172105 NM_001185177 NP_001172106 NM_024922 NP_079198 NM_012122 |
Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000250}. |
Tissue Specificity | Expressed in liver, colon and small intestine. {ECO:0000269|PubMed:14581373, ECO:0000269|PubMed:15100172, ECO:0000269|PubMed:15687373}. |
Human CES3 full length protein - ab161665 from Abcam
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Carboxylesterase 3 / CES3 Antibody Blocking Peptide - LS-E22646 from LifeSpan Bioscience
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Carboxylesterase 3 / CES3 Antibody Blocking Peptide - LS-E22647 from LifeSpan Bioscience
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Carboxylesterase 3/CES3/Esterase 31 Recombinant Protein - H00023491-P01 from Novus Biologicals
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CES3 Blocking Peptide - 33R-10383 from Fitzgerald
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CES3 - H00023491-P01-10 from Acris Antibodies
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CES3 - H00023491-P01-25 from Acris Antibodies
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CES3 fusion protein - ag6419 from Proteintech Group
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CES3 fusion protein - Ag6113 from Proteintech Group
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Recombinant Human CES3, His tagged - CES3-899H from Creative Biomart
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Recombinant Human CES3, GST-tagged - CES3-898H from Creative Biomart
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CES3 - PN201451 from Elabscience
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Recombinant Human Carboxylesterase 3(CES3) - CSB-YP005260HU CSB-EP005260HU CSB-BP005260HU CSB-MP005260HU from Cusabio
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CES3 - TP322209 from Acris Antibodies
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Carboxylesterase 3 (CES3), Recombinant Protein - MBS1346199 from MyBioSource
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Carboxylesterase 3/CES3/Esterase 31 Recombinant Protein Antigen - NBP2-47529PEP from Novus Biologicals
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Carboxylesterase 3/CES3/Esterase 31 Recombinant Protein Antigen - NBP2-48728PEP from Novus Biologicals
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CES3-Antibody-C-term-Blocking-Peptide - BP9674b from Abgent, a WuXi AppTec company
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CES3 Peptide, Human - M34GP03021H from Creative Peptides
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Recombinant Mouse Carboxylesterase 3/CES3 Protein, CF - 5428-CE from Novus Biologicals
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