Gene Symbol | CES3 |
---|---|
Entrez Gene | 23491 |
Alt Symbol | ES31 |
Species | Human |
Gene Type | protein-coding |
Description | carboxylesterase 3 |
Other Description | carboxylesterase 3 (brain)|esterase 31|liver carboxylesterase 31 homolog |
Swissprots | Q9H6X7 Q7Z6J1 B2Z3W9 F5H242 Q6UWW8 |
Accessions | ACD11491 EAW83060 EAW83062 Q6UWW8 AK000105 AK025158 AK025171 AK025389 BAB15123 AK097538 BAC05093 AY358609 AAQ88972 BC053670 AAH53670 DA924627 XM_011522975 XP_011521277 XM_011522976 XP_011521278 NM_001185176 NP_001172105 NM_001185177 NP_001172106 NM_024922 NP_079198 NM_012122 |
Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000250}. |
Tissue Specificity | Expressed in liver, colon and small intestine. {ECO:0000269|PubMed:14581373, ECO:0000269|PubMed:15100172, ECO:0000269|PubMed:15687373}. |