Gene Symbol | CES3 |
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Entrez Gene | 23491 |
Alt Symbol | ES31 |
Species | Human |
Gene Type | protein-coding |
Description | carboxylesterase 3 |
Other Description | carboxylesterase 3 (brain)|esterase 31|liver carboxylesterase 31 homolog |
Swissprots | Q9H6X7 Q7Z6J1 B2Z3W9 F5H242 Q6UWW8 |
Accessions | ACD11491 EAW83060 EAW83062 Q6UWW8 AK000105 AK025158 AK025171 AK025389 BAB15123 AK097538 BAC05093 AY358609 AAQ88972 BC053670 AAH53670 DA924627 XM_011522975 XP_011521277 XM_011522976 XP_011521278 NM_001185176 NP_001172105 NM_001185177 NP_001172106 NM_024922 NP_079198 NM_012122 |
Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000250}. |
Tissue Specificity | Expressed in liver, colon and small intestine. {ECO:0000269|PubMed:14581373, ECO:0000269|PubMed:15100172, ECO:0000269|PubMed:15687373}. |
CES3 CRISPR/Cas9 KO Plasmid (h) - sc-411749 from Santa Cruz Biotechnology
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CES3 HDR Plasmid (h) - sc-411749-HDR from Santa Cruz Biotechnology
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CES3 Double Nickase Plasmid (h) - sc-411749-NIC from Santa Cruz Biotechnology
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CES3 Double Nickase Plasmid (h2) - sc-411749-NIC-2 from Santa Cruz Biotechnology
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CES3 CRISPR Activation Plasmid (h) - sc-411749-ACT from Santa Cruz Biotechnology
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CES3 CRISPR Activation Plasmid (h2) - sc-411749-ACT-2 from Santa Cruz Biotechnology
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CES3 Lentiviral Activation Particles (h) - sc-411749-LAC from Santa Cruz Biotechnology
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CES3 Lentiviral Activation Particles (h2) - sc-411749-LAC-2 from Santa Cruz Biotechnology
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CES3 siRNA (h) - sc-72874 from Santa Cruz Biotechnology
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CES3 shRNA Plasmid (h) - sc-72874-SH from Santa Cruz Biotechnology
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CES3 shRNA (h) Lentiviral Particles - sc-72874-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136611 from Sigma-Aldrich
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MISSION® esiRNA - EHU105781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5987 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5987 from Sigma-Aldrich
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CES3 siRNA (Human) - CRH8302 from Cohesion Biosciences
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CES3 - MBS8210328 from MyBioSource
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shRNA set against Human CES3 (NM_024922.5) - SHH262261 from Creative biogene
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CES3 shRNA Plasmid (Human) - CHH8302 from Cohesion Biosciences
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CES3 miRNA 3'UTR clone - MiUTR4H-TG02028 from Creative biogene
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