| Gene Symbol |
RILP
|
| Entrez Gene |
83547
|
| Alt Symbol |
PP10141
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rab interacting lysosomal protein
|
| Other Description |
rab-interacting lysosomal protein
|
| Swissprots |
Q9BYS3 B2RBQ8 Q71RE6 Q96NA2 Q9BSL3
|
| Accessions |
EAW90595 Q96NA2 AF370391 AAQ15227 AJ278711 CAC82174 AJ404317 CAC33443 AK055755 BAB71003 AK314767 BAG37305 BC004961 AAH04961 BC031621 AAH31621 DQ892467 ABM83393 DQ895680 ABM86606 XM_005256811 XP_005256868 XM_006725257 XP_006725320 NM_031430 NP_113618
|
| Function |
Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11696325, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488}.
|
| Subcellular Location |
Endomembrane system. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes.
|
| Tissue Specificity |
Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain. {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11520070, ECO:0000269|PubMed:14668488}.
|
| Top Pathways |
Phagosome, Salmonella infection
|