Gene Symbol | RILP |
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Entrez Gene | 83547 |
Alt Symbol | PP10141 |
Species | Human |
Gene Type | protein-coding |
Description | Rab interacting lysosomal protein |
Other Description | rab-interacting lysosomal protein |
Swissprots | Q9BYS3 B2RBQ8 Q71RE6 Q96NA2 Q9BSL3 |
Accessions | EAW90595 Q96NA2 AF370391 AAQ15227 AJ278711 CAC82174 AJ404317 CAC33443 AK055755 BAB71003 AK314767 BAG37305 BC004961 AAH04961 BC031621 AAH31621 DQ892467 ABM83393 DQ895680 ABM86606 XM_005256811 XP_005256868 XM_006725257 XP_006725320 NM_031430 NP_113618 |
Function | Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11696325, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488}. |
Subcellular Location | Endomembrane system. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes. |
Tissue Specificity | Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain. {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11520070, ECO:0000269|PubMed:14668488}. |
Top Pathways | Phagosome, Salmonella infection |
RILP CRISPR/Cas9 KO Plasmid (h) - sc-402680 from Santa Cruz Biotechnology
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RILP HDR Plasmid (h) - sc-402680-HDR from Santa Cruz Biotechnology
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RILP Double Nickase Plasmid (h) - sc-402680-NIC from Santa Cruz Biotechnology
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RILP Double Nickase Plasmid (h2) - sc-402680-NIC-2 from Santa Cruz Biotechnology
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RILP CRISPR Activation Plasmid (h) - sc-402680-ACT from Santa Cruz Biotechnology
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RILP CRISPR Activation Plasmid (h2) - sc-402680-ACT-2 from Santa Cruz Biotechnology
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RILP Lentiviral Activation Particles (h) - sc-402680-LAC from Santa Cruz Biotechnology
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RILP Lentiviral Activation Particles (h2) - sc-402680-LAC-2 from Santa Cruz Biotechnology
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RILP siRNA (h) - sc-76404 from Santa Cruz Biotechnology
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RILP shRNA Plasmid (h) - sc-76404-SH from Santa Cruz Biotechnology
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RILP shRNA (h) Lentiviral Particles - sc-76404-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN18277 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18277 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02479 from Sigma-Aldrich
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RILP siRNA (Human) - CRJ3126 from Cohesion Biosciences
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RILP - MBS8210059 from MyBioSource
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shRNA set against Human RILP (NM_031430.2) - SHH395744 from Creative biogene
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shRNA set against Human RILP(NM_031430.2) - SHR181806 from Creative biogene
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RILP shRNA Plasmid (Human) - CHJ3126 from Cohesion Biosciences
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RILP miRNA 3'UTR clone - MiUTR1H-08823 from Creative biogene
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