| Gene Symbol |
PACSIN3
|
| Entrez Gene |
29763
|
| Alt Symbol |
SDPIII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase C and casein kinase substrate in neurons 3
|
| Other Description |
SH3 domain-containing protein 6511|protein kinase C and casein kinase substrate in neurons protein 3|syndapin III
|
| Swissprots |
Q9H331 Q9NWV9 Q9UKS6 A6NH84
|
| Accessions |
EAW67960 EAW67961 EAW67962 Q9UKS6 AB528520 BAI46684 AF130979 AAF04472 AF149825 AAG31023 AF242530 AAK29207 AK000577 BAA91267 AK300658 BAG62344 AK300968 BAG62592 AK310819 BC007914 AAH07914 BC011889 AAH11889 BI601317 DQ893156 ABM84082 DQ896450 ABM87449 NM_001184974 NP_001171903 NM_001184975 NP_001171904 NM_016223 NP_057307
|
| Function |
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11179684}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the inner aspect of the plasma membrane in myotubes. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}.
|
![Western Blot: PACSIN3 Overexpression Lysate (Adult Normal) [NBL1-14060] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PACSIN3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1946_PACSIN3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14060-img0002.jpg)