Gene Symbol | PACSIN3 |
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Entrez Gene | 29763 |
Alt Symbol | SDPIII |
Species | Human |
Gene Type | protein-coding |
Description | protein kinase C and casein kinase substrate in neurons 3 |
Other Description | SH3 domain-containing protein 6511|protein kinase C and casein kinase substrate in neurons protein 3|syndapin III |
Swissprots | Q9H331 Q9NWV9 Q9UKS6 A6NH84 |
Accessions | EAW67960 EAW67961 EAW67962 Q9UKS6 AB528520 BAI46684 AF130979 AAF04472 AF149825 AAG31023 AF242530 AAK29207 AK000577 BAA91267 AK300658 BAG62344 AK300968 BAG62592 AK310819 BC007914 AAH07914 BC011889 AAH11889 BI601317 DQ893156 ABM84082 DQ896450 ABM87449 NM_001184974 NP_001171903 NM_001184975 NP_001171904 NM_016223 NP_057307 |
Function | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11179684}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the inner aspect of the plasma membrane in myotubes. {ECO:0000250}. |
Tissue Specificity | Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}. |
Human PACSIN3 peptide - ab22870 from Abcam
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Human PACSIN3 protein fragment - ab162231 from Abcam
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PACSIN3 Antibody Blocking Peptide - LS-E25281 from LifeSpan Bioscience
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PACSIN3 Antibody Blocking Peptide - LS-E22675 from LifeSpan Bioscience
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PACSIN3 Antibody Blocking Peptide - LS-E9486 from LifeSpan Bioscience
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Recombinant Human PACSIN3 Protein - H00029763-Q01 from Novus Biologicals
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PACSIN3 Peptide - P3089 from Novus Biologicals
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PACSIN3-Antibody-N-term-Blocking-Peptide - BP8089a from Abgent, a WuXi AppTec company
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PACSIN3 blocking peptide - GTX22226-PEP from GeneTex
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PACSIN3 Peptide - AC21-0109-P from Abcore
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PACSIN3 - H00029763-Q01-10 from Acris Antibodies
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PACSIN3 - H00029763-Q01-25 from Acris Antibodies
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PACSIN3 Peptide - 46-125P from ProSci
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PACSIN3 fusion protein - ag1006 from Proteintech Group
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Recombinant Human Protein kinase C and casein kinase substrate in neurons protein 3(PACSIN3) - CSB-YP892456HU CSB-EP892456HU CSB-BP892456HU CSB-MP892456HU from Cusabio
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PACSIN3 - TP304103 from Acris Antibodies
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PACSIN3, Peptide - MBS426171 from MyBioSource
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PACSIN3 Recombinant Protein Antigen - NBP2-47339PEP from Novus Biologicals
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PACSIN3 Recombinant Protein Antigen - NBP2-48707PEP from Novus Biologicals
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PACSIN3-Antibody-Center-Blocking-Peptide - BP8089c from Abgent, a WuXi AppTec company
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PACSIN3 Peptide, Human - M34GP11236H from Creative Peptides
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PACSIN3 Antibody - SH-A14279 from Novatein Biosciences
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Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3), Recombinant Protein - MBS1344210 from MyBioSource
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PACSIN3 Immunizing peptide - orb15420 from Biorbyt
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