Gene Symbol | PACSIN3 |
---|---|
Entrez Gene | 29763 |
Alt Symbol | SDPIII |
Species | Human |
Gene Type | protein-coding |
Description | protein kinase C and casein kinase substrate in neurons 3 |
Other Description | SH3 domain-containing protein 6511|protein kinase C and casein kinase substrate in neurons protein 3|syndapin III |
Swissprots | Q9H331 Q9NWV9 Q9UKS6 A6NH84 |
Accessions | EAW67960 EAW67961 EAW67962 Q9UKS6 AB528520 BAI46684 AF130979 AAF04472 AF149825 AAG31023 AF242530 AAK29207 AK000577 BAA91267 AK300658 BAG62344 AK300968 BAG62592 AK310819 BC007914 AAH07914 BC011889 AAH11889 BI601317 DQ893156 ABM84082 DQ896450 ABM87449 NM_001184974 NP_001171903 NM_001184975 NP_001171904 NM_016223 NP_057307 |
Function | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11179684}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the inner aspect of the plasma membrane in myotubes. {ECO:0000250}. |
Tissue Specificity | Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}. |