MOB1B

Gene Symbol	MOB1B
Entrez Gene	92597
Alt Symbol	MATS2, MOB4A, MOBKL1A
Species	Human
Gene Type	protein-coding
Description	MOB kinase activator 1B
Other Description	MOB1 Mps One Binder homolog B\|MOB1, Mps One Binder kinase activator-like 1A\|mob1 homolog 1A\|mob1A\|mps one binder kinase activator-like 1A
Swissprots	B2R8U6 Q8IY23 B4DRY3 Q7L9L4
Accessions	AAY40943 AAY41047 EAX05635 EAX05636 Q7L9L4 AA417950 AJ577473 CAE12091 AK093545 BAG52738 AK299481 BAG61445 AK313513 BAG36293 AL162039 BC038112 AAH38112 BC044913 BF129919 BG033976 BG433921 BQ229138 BX089615 CA311370 XM_005265709 XP_005265766 XM_011532412 XP_011530714 NM_001244766 NP_001231695 NM_001244767 NP_001231696 NM_173468 NP_775739
Function	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269\|PubMed:15067004, ECO:0000269\|PubMed:19739119}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:15067004}. Nucleus {ECO:0000269\|PubMed:15067004}.
Tissue Specificity	Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. {ECO:0000269\|PubMed:19739119}.
Top Pathways	Hippo signaling pathway

MOB1B (C-18) - sc-130175 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

MOB1B (C-18): sc-130175. Immunoperoxidase staining of formalin fixed, paraffin-embedded human brain tissue showing cytoplasmic staining.

Anti-MOB4A antibody - ab179932 from Abcam

Prices	$407.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labelling MOB4A with ab179932 at 20 µg/ml.

Anti-MOB4A antibody - ab62894 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MOB4A antibody (ab62894) at 1/100 dilution + Ramos cell lysate at 35 µg

Anti-MOB4A antibody - ab72757 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MOB4A antibody (ab72757) at 1/500 dilutionLane 1 : 293 cell extract treated with IFN (2500U/ml, 30mins)Lane 2 : Cos7 cell extract treated with IFN (2500U/ml, 30mins)Lane 3 : HUVEC extract treated with IFN (2500U/ml, 30mins)Lane 4 : 293 cell extract treated with IFN (2500U/ml, 30mins) with immunising peptide at 10 µgLysates/proteins at 10 µg per lane.

Anti-MOB4A antibody [3G9] - ab118983 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3G9

All lanes : Anti-MOB4A antibody [3G9] (ab118983) at 1/500 dilutionLane 1 : HEK293T cells were transfected with the pCMV6-ENTRY control Lane 2 : HEK293T cells were transfected with the pCMV6-MOB4ALysates/proteins at 5 µg per lane.

Anti-MOB4A antibody - C-terminal - ab199166 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MOB4A antibody - C-terminal (ab199166) at 1/225 dilutionLane 1 : Jurkat cell lysateLane 2 : K562 cell lysateLane 3 : mouse testis tissue lysateLysates/proteins at 40 µg per lane.

Anti-MOB1B / MOBKL1A Antibody (clone 1F6) - LS-C115354 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1F6

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MOBKL1A (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MOBKL1A.

Anti-MOB1B / MOBKL1A Antibody (clone 1H8) - LS-C115343 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1H8

Anti-MOB1B / MOBKL1A Antibody (aa177-206) - LS-C98948 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human brain tissue reacted with MOB4A antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-MOB1B / MOBKL1A Antibody (C-Terminus, AP) - LS-C245045 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (C-Terminus, FITC) - LS-C245047 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (C-Terminus, APC) - LS-C245046 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (C-Terminus, Biotin) - LS-C245048 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (C-Terminus, PE) - LS-C245049 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (N-Terminus, AP) - LS-C245050 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (C-Terminus) - LS-C151955 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MOB1B / MOBKL1A antibody Western Blot of Jurkat cell lysate.

Anti-MOB1B / MOBKL1A Antibody (aa85-134) - LS-C151956 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MOB1B / MOBKL1A antibody Western Blot of Jurkat.

Anti-MOB1B / MOBKL1A Antibody (N-Terminus, APC) - LS-C245051 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (N-Terminus, Biotin) - LS-C245052 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (N-Terminus, FITC) - LS-C245053 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (N-Terminus, PE) - LS-C245057 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (C-Terminus, Azide-free, HRP) - LS-C247704 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (N-Terminus, Azide-free, HRP) - LS-C247705 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (N-Terminus) - LS-C327920 from LifeSpan Bioscience

Prices	$425.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MOB1B / MOBKL1A Antibody (aa120-217) - LS-C309037 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

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