MOB1B

Gene Symbol	MOB1B
Entrez Gene	92597
Alt Symbol	MATS2, MOB4A, MOBKL1A
Species	Human
Gene Type	protein-coding
Description	MOB kinase activator 1B
Other Description	MOB1 Mps One Binder homolog B|MOB1, Mps One Binder kinase activator-like 1A|mob1 homolog 1A|mob1A|mps one binder kinase activator-like 1A
Swissprots	B2R8U6 Q8IY23 B4DRY3 Q7L9L4
Accessions	AAY40943 AAY41047 EAX05635 EAX05636 Q7L9L4 AA417950 AJ577473 CAE12091 AK093545 BAG52738 AK299481 BAG61445 AK313513 BAG36293 AL162039 BC038112 AAH38112 BC044913 BF129919 BG033976 BG433921 BQ229138 BX089615 CA311370 XM_005265709 XP_005265766 XM_011532412 XP_011530714 NM_001244766 NP_001231695 NM_001244767 NP_001231696 NM_173468 NP_775739
Function	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15067004}. Nucleus {ECO:0000269|PubMed:15067004}.
Tissue Specificity	Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. {ECO:0000269|PubMed:19739119}.
Top Pathways	Hippo signaling pathway

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• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MOBKL1A-Over-expression-Lysate - LY10778a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

MOB1B overexpression lysate - LY406621 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MOBKL1A 293 Cell Lysate - 403985 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

MOB4A Overexpression Lysate (Native) - NBL1-13169 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

MOBKL1A Over-expression Lysate Product - GWB-6B9DB8 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human MOB1B Knockdown Stable Cell Line - CSC-DC009626 from Creative biogene Category Cell Line Species Human

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