| Gene Symbol |
MOB1B
|
| Entrez Gene |
92597
|
| Alt Symbol |
MATS2, MOB4A, MOBKL1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MOB kinase activator 1B
|
| Other Description |
MOB1 Mps One Binder homolog B|MOB1, Mps One Binder kinase activator-like 1A|mob1 homolog 1A|mob1A|mps one binder kinase activator-like 1A
|
| Swissprots |
B2R8U6 Q8IY23 B4DRY3 Q7L9L4
|
| Accessions |
AAY40943 AAY41047 EAX05635 EAX05636 Q7L9L4 AA417950 AJ577473 CAE12091 AK093545 BAG52738 AK299481 BAG61445 AK313513 BAG36293 AL162039 BC038112 AAH38112 BC044913 BF129919 BG033976 BG433921 BQ229138 BX089615 CA311370 XM_005265709 XP_005265766 XM_011532412 XP_011530714 NM_001244766 NP_001231695 NM_001244767 NP_001231696 NM_173468 NP_775739
|
| Function |
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15067004}. Nucleus {ECO:0000269|PubMed:15067004}.
|
| Tissue Specificity |
Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. {ECO:0000269|PubMed:19739119}.
|
| Top Pathways |
Hippo signaling pathway
|