MOB1B

Gene Symbol	MOB1B
Entrez Gene	92597
Alt Symbol	MATS2, MOB4A, MOBKL1A
Species	Human
Gene Type	protein-coding
Description	MOB kinase activator 1B
Other Description	MOB1 Mps One Binder homolog B|MOB1, Mps One Binder kinase activator-like 1A|mob1 homolog 1A|mob1A|mps one binder kinase activator-like 1A
Swissprots	B2R8U6 Q8IY23 B4DRY3 Q7L9L4
Accessions	AAY40943 AAY41047 EAX05635 EAX05636 Q7L9L4 AA417950 AJ577473 CAE12091 AK093545 BAG52738 AK299481 BAG61445 AK313513 BAG36293 AL162039 BC038112 AAH38112 BC044913 BF129919 BG033976 BG433921 BQ229138 BX089615 CA311370 XM_005265709 XP_005265766 XM_011532412 XP_011530714 NM_001244766 NP_001231695 NM_001244767 NP_001231696 NM_173468 NP_775739
Function	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15067004}. Nucleus {ECO:0000269|PubMed:15067004}.
Tissue Specificity	Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. {ECO:0000269|PubMed:19739119}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MOB4A full length protein - ab140717 from Abcam Category Protein Source E. coli Species Human

MOB1B / MOBKL1A Antibody Blocking Peptide - LS-E8625 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MOB1B / MOBKL1A Antibody Blocking Peptide - LS-E23791 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MOB1B / MOBKL1A Antibody Blocking Peptide - LS-E23790 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MOB4A Partial Recombinant Protein - H00092597-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MOB4A Recombinant Protein - H00092597-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MOB4A Protein - NBP2-23248 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

MOB4A Peptide - P2122 from Novus Biologicals Category Peptide Species Human

MOB4A-Antibody-C-term-Blocking-Peptide - BP7031b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MOBKL1A protein (GST Tag) - orb139350 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

MOB1B protein (His tag) - 80R-2730 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

MOB4A (1-216, His-tag) - AR50850PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

MOB4A (1-216, His-tag) - AR50850PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

MOB4A - H00092597-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MOB4A - H00092597-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MOB4A - H00092597-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MOB4A - H00092597-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MOB1B, 1-216aa, Human, His tag, E.coli - 01-P2026 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

MOBKL1A fusion protein - Ag3509 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MOB1B, His-tagged - MOB1B-7582H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MOB1B, GST tagged - MOB1B-507H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MOBKL1A, GST-tagged - MOBKL1A-927H from Creative Biomart Category Protein Source E.coli Species Human

Human MOBKL1A / MOB1B Protein (GST Tag) - 14016-H09E-20 from Sino Biological Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source E. coli Species Human

MOB1B Blocking Peptide - CBP4089 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Monkey, Zebrafish

Recombinant Human MOB kinase activator 1B(MOB1B) - CSB-YP762574HU CSB-EP762574HU CSB-BP762574HU CSB-MP762574HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Search more