| Gene Symbol | MOB1B |
|---|---|
| Entrez Gene | 92597 |
| Alt Symbol | MATS2, MOB4A, MOBKL1A |
| Species | Human |
| Gene Type | protein-coding |
| Description | MOB kinase activator 1B |
| Other Description | MOB1 Mps One Binder homolog B|MOB1, Mps One Binder kinase activator-like 1A|mob1 homolog 1A|mob1A|mps one binder kinase activator-like 1A |
| Swissprots | B2R8U6 Q8IY23 B4DRY3 Q7L9L4 |
| Accessions | AAY40943 AAY41047 EAX05635 EAX05636 Q7L9L4 AA417950 AJ577473 CAE12091 AK093545 BAG52738 AK299481 BAG61445 AK313513 BAG36293 AL162039 BC038112 AAH38112 BC044913 BF129919 BG033976 BG433921 BQ229138 BX089615 CA311370 XM_005265709 XP_005265766 XM_011532412 XP_011530714 NM_001244766 NP_001231695 NM_001244767 NP_001231696 NM_173468 NP_775739 |
| Function | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15067004}. Nucleus {ECO:0000269|PubMed:15067004}. |
| Tissue Specificity | Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. {ECO:0000269|PubMed:19739119}. |
| Top Pathways | Hippo signaling pathway |
MOB1B CRISPR/Cas9 KO Plasmid (h) - sc-416280 from Santa Cruz Biotechnology
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MOB1B HDR Plasmid (h) - sc-416280-HDR from Santa Cruz Biotechnology
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MOB1B Double Nickase Plasmid (h) - sc-416280-NIC from Santa Cruz Biotechnology
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MOB1B Double Nickase Plasmid (h2) - sc-416280-NIC-2 from Santa Cruz Biotechnology
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MOB1B CRISPR Activation Plasmid (h) - sc-416280-ACT from Santa Cruz Biotechnology
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MOB1B CRISPR Activation Plasmid (h2) - sc-416280-ACT-2 from Santa Cruz Biotechnology
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MOB1B Lentiviral Activation Particles (h) - sc-416280-LAC from Santa Cruz Biotechnology
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MOB1B Lentiviral Activation Particles (h2) - sc-416280-LAC-2 from Santa Cruz Biotechnology
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MOB1B siRNA (h) - sc-88864 from Santa Cruz Biotechnology
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MOB1B shRNA Plasmid (h) - sc-88864-SH from Santa Cruz Biotechnology
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MOB1B shRNA (h) Lentiviral Particles - sc-88864-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU030151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14452 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14452 from Sigma-Aldrich
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MOB1B siRNA (Human) - CRJ4151 from Cohesion Biosciences
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shRNA set against Human MOBKL1A (NM_173468.3) - SHH343276 from Creative biogene
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Human MOB1B siRNA - orb274652 from Biorbyt
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MOB1B shRNA Plasmid (Human) - CHJ4151 from Cohesion Biosciences
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