| Gene Symbol |
BRD7
|
| Entrez Gene |
29117
|
| Alt Symbol |
BP75, CELTIX1, NAG4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bromodomain containing 7
|
| Other Description |
75 kDa bromodomain protein|bromodomain-containing protein 7|protein CELTIX-1
|
| Swissprots |
Q9BV48 Q8N2L9 Q96KA4 Q4VC09 Q9UH59 Q9NPI1
|
| Accessions |
EAW82756 EAW82757 EAW82758 EAW82759 Q9NPI1 AF152604 AAF75126 AF213969 AAF19526 AJ271881 CAB72445 AK027308 BAB55031 AK074613 BAC11089 AW615116 BC001611 AAH01611 BC050728 AAH50728 BC094706 AAH94706 CD677718 DA645362 XM_011523046 XP_011521348 XM_011523047 XP_011521349 XM_011523048 XP_011521350 XM_011523049 XP_011521351 XM_011523050 XP_011521352 XR_933289 XR_933290 XR_933291 NM_001173984 NP_001167455 NM_013263 NP_037395
|
| Function |
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMe
|
| Subcellular Location |
Isoform 2: Nucleus.
|