ZAP70
| Gene Symbol | ZAP70 |
|---|---|
| Entrez Gene | 7535 |
| Alt Symbol | SRK, STCD, STD, TZK, ZAP-70 |
| Species | Human |
| Gene Type | protein-coding |
| Description | zeta-chain (TCR) associated protein kinase 70kDa |
| Other Description | 70 kDa zeta-associated protein|70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70|zeta-chain associated protein kinase, 70kD |
| Swissprots | Q6PIA4 A6NFP4 Q9UBS6 P43403 Q8IXD6 |
| Accessions | AAX93187 EAX01918 EAX01919 P43403 AB083211 BAC43747 AK303341 BAG64404 AK310628 AK310637 AL832287 BC039039 AAH39039 BC053878 AAH53878 L05148 XM_005264015 XP_005264072 XM_006712728 XP_006712791 XM_011511783 XP_011510085 XR_923018 XR_923019 XR_923020 NM_001079 NP_001070 NM_207519 NP_997402 |
| Function | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, ad |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9813084}. Cell membrane {ECO:0000269|PubMed:9813084}; Peripheral membrane protein {ECO:0000269|PubMed:9813084}. Note=In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in T- and natural killer cells. Also present in early thymocytes and pro/pre B-cells. {ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:16467082, ECO:0000269|PubMed:9378960}. |
| Top Pathways | Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Primary immunodeficiency |
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