ZAP70

Gene Symbol	ZAP70
Entrez Gene	7535
Alt Symbol	SRK, STCD, STD, TZK, ZAP-70
Species	Human
Gene Type	protein-coding
Description	zeta-chain (TCR) associated protein kinase 70kDa
Other Description	70 kDa zeta-associated protein|70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70|zeta-chain associated protein kinase, 70kD
Swissprots	Q6PIA4 A6NFP4 Q9UBS6 P43403 Q8IXD6
Accessions	AAX93187 EAX01918 EAX01919 P43403 AB083211 BAC43747 AK303341 BAG64404 AK310628 AK310637 AL832287 BC039039 AAH39039 BC053878 AAH53878 L05148 XM_005264015 XP_005264072 XM_006712728 XP_006712791 XM_011511783 XP_011510085 XR_923018 XR_923019 XR_923020 NM_001079 NP_001070 NM_207519 NP_997402
Function	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, ad
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9813084}. Cell membrane {ECO:0000269|PubMed:9813084}; Peripheral membrane protein {ECO:0000269|PubMed:9813084}. Note=In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in T- and natural killer cells. Also present in early thymocytes and pro/pre B-cells. {ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:16467082, ECO:0000269|PubMed:9378960}.
Top Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ZAP70 full length protein - ab152810 from Abcam Category Protein Prices $410.00 Sizes 10 µg Source Wheat germ Species Human

Active human ZAP70 full length protein - ab79644 from Abcam Category Protein Prices $343.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human ZAP70 full length protein - ab60963 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human ZAP70 protein fragment - ab152811 from Abcam Category Protein Source Wheat germ Species Human

ZAP70 (phospho Y492) peptide - ab179531 from Abcam Category Peptide

ZAP70 Antibody Blocking Peptide - LS-E3013 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZAP70 Antibody Blocking Peptide - LS-E3012 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZAP70 Antibody Blocking Peptide - LS-E3893 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZAP70 Antibody Blocking Peptide - LS-E27844 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZAP70 Antibody Blocking Peptide - LS-E22374 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZAP70 Antibody Blocking Peptide - LS-E22373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZAP70 Recombinant Protein - H00007535-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ZAP70 Partial Recombinant Protein - H00007535-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human ZAP70 Protein - P4235 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Source Insect Species Human

ZAP70 Recombinant Protein - P4798 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant ZAP70 Protein - NBP1-99479 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Phospho-ErbB2-pY1248M-Blocking-Peptide - BP3661a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

ZAP70-Antibody-Center-Y492493-Blocking-peptide - BP12904c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZAP70-Antibody-Center-Y292-Blocking-peptide - BP12903c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZAP70-Antibody-N-term-Blocking-peptide - BP14146a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZAP70-Antibody-Center-Blocking-peptide - BP14145c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZAP70 (Active) recombinant protein - GTX65283 from GeneTex Category Protein Prices $249.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human Active ZAP70, CF - 3709-KS-010 from R&D Systems Category Protein

ZAP70 Blocking Peptide - 33R-6365 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ZAP70 protein - 30R-2866 from Fitzgerald Category Protein Prices $250.00 Sizes 5 µg Source Sf-9 insect cells Species Human

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