Gene Symbol | BMP10 |
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Entrez Gene | 27302 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | bone morphogenetic protein 10 |
Other Description | - |
Swissprots | Q53R17 O95393 Q6NTE0 |
Accessions | AAY15075 EAW99863 O95393 AF101441 AAC77462 BC069080 AAH69080 BC101734 AAI01735 BC105063 AAI05064 NM_014482 NP_055297 |
Function | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. {ECO:0000269|PubMed:16049014, ECO:0000269|PubMed:17068149, ECO:0000269|PubMed:20608934}. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Detected in mammary epithelia (at protein level). {ECO:0000269|PubMed:20608934}. |
BMP-10 (G-15) - sc-163745 from Santa Cruz Biotechnology
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BMP-10 (N-21) - sc-130121 from Santa Cruz Biotechnology
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Anti-BMP10 antibody - ab118398 from Abcam
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Anti-BMP10 antibody - ab34962 from Abcam
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Anti-BMP10 antibody - ab96593 from Abcam
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Anti-BMP10 antibody - ab172510 from Abcam
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Anti-BMP10 antibody [MM0113-5L26] - ab89300 from Abcam
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Anti-BMP10 antibody - N-terminal - ab172987 from Abcam
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Anti-BMP10 Antibody (aa22-35) IHC-plus⢠- LS-B202 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa360-424) - LS-C185983 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa7-35) IHC-plus⢠- LS-B6907 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa86-96) - LS-C41783 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa20-313) - LS-C35175 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa22-35) - LS-C121126 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa317-424, clone MAB2926) - LS-C125194 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa84-94) - LS-C127072 from LifeSpan Bioscience
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Anti-BMP10 Antibody - LS-C147138 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa314-421, clone 11n14) - LS-C184179 from LifeSpan Bioscience
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Anti-BMP10 Antibody (N-Terminus, AP) - LS-C243829 from LifeSpan Bioscience
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Anti-BMP10 Antibody (N-Terminus, APC) - LS-C243828 from LifeSpan Bioscience
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Anti-BMP10 Antibody (N-Terminus, Biotin) - LS-C243830 from LifeSpan Bioscience
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Anti-BMP10 Antibody (N-Terminus, PE) - LS-C243836 from LifeSpan Bioscience
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Anti-BMP10 Antibody (N-Terminus, FITC) - LS-C243831 from LifeSpan Bioscience
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Anti-BMP10 Antibody (N-Terminus, Azide-free, HRP) - LS-C247469 from LifeSpan Bioscience
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Anti-BMP10 Antibody (aa315-424, Biotin) - LS-C298132 from LifeSpan Bioscience
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