| Gene Symbol |
PRKAR2B
|
| Entrez Gene |
5577
|
| Alt Symbol |
PRKAR2, RII-BETA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase, cAMP-dependent, regulatory, type II, beta
|
| Other Description |
H_RG363E19.2|WUGSC:H_RG363E19.2|cAMP-dependent protein kinase type II-beta regulatory chain|cAMP-dependent protein kinase type II-beta regulatory subunit
|
| Swissprots |
A4D0R9 P31323
|
| Accessions |
AAC08318 AAS07389 ABO15447 EAL24395 EAW83390 EAW83391 P31323 AK128639 BAG54705 AK291441 BAF84130 AL559918 AM392728 CAL37606 AM392771 CAL37649 AM393258 CAL38136 AM393700 CAL38576 BC014355 BC075800 AAH75800 BQ022817 CA405423 CF593944 M31158 AAA60099 XM_011516398 XP_011514700 XM_011516399 XP_011514701 NM_002736 NP_002727
|
| Function |
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
|
| Tissue Specificity |
Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
|
| Top Pathways |
Apoptosis, Insulin signaling pathway
|
![Western Blot: PKA 2 beta Overexpression Lysate (Adult Normal) [NBL1-14768] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PKA 2 beta.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9814_PKA%25202%2520beta%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14768-img0002.jpg)