PRKAR2B

Gene Symbol PRKAR2B
Entrez Gene 5577
Alt Symbol PRKAR2, RII-BETA
Species Human
Gene Type protein-coding
Description protein kinase, cAMP-dependent, regulatory, type II, beta
Other Description H_RG363E19.2|WUGSC:H_RG363E19.2|cAMP-dependent protein kinase type II-beta regulatory chain|cAMP-dependent protein kinase type II-beta regulatory subunit
Swissprots A4D0R9 P31323
Accessions AAC08318 AAS07389 ABO15447 EAL24395 EAW83390 EAW83391 P31323 AK128639 BAG54705 AK291441 BAF84130 AL559918 AM392728 CAL37606 AM392771 CAL37649 AM393258 CAL38136 AM393700 CAL38576 BC014355 BC075800 AAH75800 BQ022817 CA405423 CF593944 M31158 AAA60099 XM_011516398 XP_011514700 XM_011516399 XP_011514701 NM_002736 NP_002727
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
Tissue Specificity Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Top Pathways Apoptosis, Insulin signaling pathway

PKA IIβ reg (C-16) - sc-18803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PKA IIβ reg (E-20) - sc-18802 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PKA IIβ reg (E-20): sc-18802. Western blot analysis of PKA IIβ reg expression in rat testis extract (A) and F9 whole cell lysate (B).

PKA IIβ reg (H-90) - sc-25424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PKA IIβ reg (H-90): sc-25424. Immunofluorescence staining of normal mouse liver frozen section showing cytoplasmic staining.

PKA IIβ reg (L-16) - sc-26803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PKA IIβ reg (L-16): sc-26803. Western blot analysis of PKA IIβ reg expression in ES-2 whole cell lysate.

PKA IIβ reg (A-20) - sc-23792 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PKA IIβ reg (A-20): sc-23792. Western blot analysis of PKA IIβ reg expression in IMR-32 (A), NTERA-2 cl.D1 (B) and U-251-MG (C) whole cell lysates.

p-PKA IIβ reg (pS114.47) - sc-136185 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p-PKA IIβ reg (pS114.47): sc-136185. Western blot analysis of PKA IIβ reg phosphorylation in rat cerebrum tissue extracts either untreated (A) or treated (B) with lambda phosphatase.

Anti-PKA 2 beta (regulatory subunit) (phospho S113) antibody - ab138679 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PKA 2 beta (regulatory subunit) (phospho S113) antibody (ab138679) at 1/500 dilution + COS7 cell extract, treated with PMA (125ng/ml for 30 mins) at 30 µg

Anti-PKA 2 beta (regulatory subunit) antibody - ab28256 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab28256 staining human normal breast tissue. Staining is localized to cytoplasm.Left panel: with primary antibody at 2 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffers EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-PKA 2 beta (regulatory subunit) antibody - ab189266 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded, formalin-fixed Human brain, cortex, tissue labeling PKA 2 beta (regulatory subunit) using ab189266 at 10 µg/ml.

Anti-PKA 2 beta (regulatory subunit) antibody - ab73940 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKA 2 beta (regulatory subunit) antibody (ab73940) at 1/500 dilutionLane 1 : Extracts from HepG2 cells.Lane 2 : Extracts from K562 cells.Lane 3 : Extracts from K562 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-PKA 2 beta (regulatory subunit) antibody - ab38222 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PKA 2 beta (regulatory subunit) antibody (ab38222) at 1/100 dilution + mouse brain tissue lysate

Anti-PKA 2 beta (regulatory subunit) antibody [EP2648] - ab75996 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2648
Overlay histogram showing SHSY-5Y cells stained with ab75996 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab75996, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-PKA 2 beta (regulatory subunit) antibody [EP2649Y] - ab75993 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2649Y
Anti-PKA 2 beta (regulatory subunit) antibody [EP2649Y] (ab75993) at 1/50000 dilution + Human brain lysate at 10 µgSecondarygoat anti rabbit HRP at 1/2000 dilution

Anti-PRKAR2B Antibody (aa79-128) IHC-plus™ - LS-B7655 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PRKAR2B antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7655 concentration 10 ug/ml.

Anti-PRKAR2B Antibody (phospho-Ser114) - LS-C38513 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody (phospho-Ser114) - LS-C38516 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody - LS-C91458 from LifeSpan Bioscience

Prices $295.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody - LS-C202985 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody (aa119-147, AP) - LS-C267098 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody (aa119-147, APC) - LS-C267099 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody (aa119-147, Biotin) - LS-C267100 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody (aa119-147, FITC) - LS-C267101 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody (aa119-147, Azide-free, HRP) - LS-C267102 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody (aa119-147, PE) - LS-C267103 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PRKAR2B Antibody (N-Terminus, clone EP2648) - LS-C105502 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2648
IHC of paraffin-embedded human brain tissue using anti-PKA, RIIb antibody (LS-C105502).
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