Gene Symbol | PRKAR2B |
---|---|
Entrez Gene | 5577 |
Alt Symbol | PRKAR2, RII-BETA |
Species | Human |
Gene Type | protein-coding |
Description | protein kinase, cAMP-dependent, regulatory, type II, beta |
Other Description | H_RG363E19.2|WUGSC:H_RG363E19.2|cAMP-dependent protein kinase type II-beta regulatory chain|cAMP-dependent protein kinase type II-beta regulatory subunit |
Swissprots | A4D0R9 P31323 |
Accessions | AAC08318 AAS07389 ABO15447 EAL24395 EAW83390 EAW83391 P31323 AK128639 BAG54705 AK291441 BAF84130 AL559918 AM392728 CAL37606 AM392771 CAL37649 AM393258 CAL38136 AM393700 CAL38576 BC014355 BC075800 AAH75800 BQ022817 CA405423 CF593944 M31158 AAA60099 XM_011516398 XP_011514700 XM_011516399 XP_011514701 NM_002736 NP_002727 |
Function | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane. |
Tissue Specificity | Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
Top Pathways | Apoptosis, Insulin signaling pathway |