| Gene Symbol |
RIC8A
|
| Entrez Gene |
60626
|
| Alt Symbol |
RIC8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RIC8 guanine nucleotide exchange factor A
|
| Other Description |
resistance to inhibitors of cholinesterase 8 homolog A|synembryn-A
|
| Swissprots |
Q9H5H3 Q9H064 Q7Z352 Q2T9J1 Q0P508 Q9H9E7 Q9NPQ8 Q96SZ2 Q96EZ1
|
| Accessions |
CAE90494 EAW61244 EAW61245 EAW61246 Q9NPQ8 AK022870 BAB14282 AK026897 AK027090 BAB15653 AK027461 BAB55126 AK225420 AK314568 AL136935 CAB66869 AL390088 CAB98211 AM393435 CAL38313 BC011821 AAH11821 BC094717 BC111499 AAI11500 BC121807 AAI21808 BC121808 AAI21809 BX538115 CAD98025 XM_005253052 XP_005253109 XM_011520267 XP_011518569 XM_011520268 XP_011518570 XM_011520269 XP_011518571 XM_011520270 XP_011518572 XM_011520271 XP_011518573 XM_011520272 XP_011518574 NM_001286134 NP_001273063 NM_021932 NP_068751
|
| Function |
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. {ECO:0000250, ECO:0000269|PubMed:16629901}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.
|
![Western Blot: RIC8 Overexpression Lysate (Adult Normal) [NBL1-15368] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RIC8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10676_RIC8%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-15368-img0002.jpg)