RIC8A

Gene Symbol	RIC8A
Entrez Gene	60626
Alt Symbol	RIC8
Species	Human
Gene Type	protein-coding
Description	RIC8 guanine nucleotide exchange factor A
Other Description	resistance to inhibitors of cholinesterase 8 homolog A|synembryn-A
Swissprots	Q9H5H3 Q9H064 Q7Z352 Q2T9J1 Q0P508 Q9H9E7 Q9NPQ8 Q96SZ2 Q96EZ1
Accessions	CAE90494 EAW61244 EAW61245 EAW61246 Q9NPQ8 AK022870 BAB14282 AK026897 AK027090 BAB15653 AK027461 BAB55126 AK225420 AK314568 AL136935 CAB66869 AL390088 CAB98211 AM393435 CAL38313 BC011821 AAH11821 BC094717 BC111499 AAI11500 BC121807 AAI21808 BC121808 AAI21809 BX538115 CAD98025 XM_005253052 XP_005253109 XM_011520267 XP_011518569 XM_011520268 XP_011518570 XM_011520269 XP_011518571 XM_011520270 XP_011518572 XM_011520271 XP_011518573 XM_011520272 XP_011518574 NM_001286134 NP_001273063 NM_021932 NP_068751
Function	Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. {ECO:0000250, ECO:0000269|PubMed:16629901}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RIC8A protein fragment - ab163734 from Abcam Category Protein Source Wheat germ Species Human

RIC8A Antibody Blocking Peptide - LS-E4735 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIC8A Antibody Blocking Peptide - LS-E25788 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIC8A Antibody Blocking Peptide - LS-E21017 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RIC8A Protein - H00060626-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RIC8A-Antibody-Center-Blocking-Peptide - BP17108c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIC8A blocking peptide - GTX89648-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

Goat anti RIC8A antibody Immunizing peptide - orb17020 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

RIC8A Blocking Peptide - 33R-4543 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Ric8A Peptide - AC21-0617-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RIC8A - H00060626-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RIC8A - H00060626-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RIC8A control peptide - AP10294CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

RIC-8A Peptide - 46-298P from ProSci Category Peptide Species Human

RIC8A fusion protein - ag1593 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Synembryn-A(RIC8A) - CSB-YP878847HU CSB-EP878847HU CSB-BP878847HU CSB-MP878847HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RIC8A - TP311359 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RIC8A/Synembryn, Peptide - MBS425503 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine

RIC8A Recombinant Protein Antigen - NBP2-47304PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RIC8A Peptide, Human - M34GP13296H from Creative Peptides Category Peptide Source Synthetic. Species Human

Synembryn-A (RIC8A), Recombinant Protein - MBS1460713 from MyBioSource Category Protein Prices $1,320.00, $1,320.00, $1,540.00, $1,540.00, $2,185.00, $2,185.00, $2,650.00, $2,650.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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