RIC8A

Gene Symbol RIC8A
Entrez Gene 60626
Alt Symbol RIC8
Species Human
Gene Type protein-coding
Description RIC8 guanine nucleotide exchange factor A
Other Description resistance to inhibitors of cholinesterase 8 homolog A|synembryn-A
Swissprots Q9H5H3 Q9H064 Q7Z352 Q2T9J1 Q0P508 Q9H9E7 Q9NPQ8 Q96SZ2 Q96EZ1
Accessions CAE90494 EAW61244 EAW61245 EAW61246 Q9NPQ8 AK022870 BAB14282 AK026897 AK027090 BAB15653 AK027461 BAB55126 AK225420 AK314568 AL136935 CAB66869 AL390088 CAB98211 AM393435 CAL38313 BC011821 AAH11821 BC094717 BC111499 AAI11500 BC121807 AAI21808 BC121808 AAI21809 BX538115 CAD98025 XM_005253052 XP_005253109 XM_011520267 XP_011518569 XM_011520268 XP_011518570 XM_011520269 XP_011518571 XM_011520270 XP_011518572 XM_011520271 XP_011518573 XM_011520272 XP_011518574 NM_001286134 NP_001273063 NM_021932 NP_068751
Function Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. {ECO:0000250, ECO:0000269|PubMed:16629901}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

RIC-8A CRISPR/Cas9 KO Plasmid (h) - sc-412946 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIC-8A HDR Plasmid (h) - sc-412946-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIC-8A Double Nickase Plasmid (h) - sc-412946-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIC-8A Double Nickase Plasmid (h2) - sc-412946-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIC-8A CRISPR Activation Plasmid (h) - sc-412946-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIC-8A CRISPR Activation Plasmid (h2) - sc-412946-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIC-8A Lentiviral Activation Particles (h) - sc-412946-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIC-8A Lentiviral Activation Particles (h2) - sc-412946-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIC-8A siRNA (h) - sc-76402 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RIC-8A shRNA Plasmid (h) - sc-76402-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RIC-8A shRNA (h) Lentiviral Particles - sc-76402-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU033251 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18273 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18273 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RIC8A siRNA (Human) - CRJ1822 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIC8A - MBS8219919 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RIC8A (NM_021932.4) - SHH395684 from Creative biogene

Category siRNA
Species Reactivities Human

Human RIC8A siRNA - orb272323 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIC8A shRNA Plasmid (Human) - CHJ1822 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RIC8A miRNA 3'UTR clone - MiUTR1H-08820 from Creative biogene

Species Reactivities Human
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