RIC8A

Gene Symbol	RIC8A
Entrez Gene	60626
Alt Symbol	RIC8
Species	Human
Gene Type	protein-coding
Description	RIC8 guanine nucleotide exchange factor A
Other Description	resistance to inhibitors of cholinesterase 8 homolog A|synembryn-A
Swissprots	Q9H5H3 Q9H064 Q7Z352 Q2T9J1 Q0P508 Q9H9E7 Q9NPQ8 Q96SZ2 Q96EZ1
Accessions	CAE90494 EAW61244 EAW61245 EAW61246 Q9NPQ8 AK022870 BAB14282 AK026897 AK027090 BAB15653 AK027461 BAB55126 AK225420 AK314568 AL136935 CAB66869 AL390088 CAB98211 AM393435 CAL38313 BC011821 AAH11821 BC094717 BC111499 AAI11500 BC121807 AAI21808 BC121808 AAI21809 BX538115 CAD98025 XM_005253052 XP_005253109 XM_011520267 XP_011518569 XM_011520268 XP_011518570 XM_011520269 XP_011518571 XM_011520270 XP_011518572 XM_011520271 XP_011518573 XM_011520272 XP_011518574 NM_001286134 NP_001273063 NM_021932 NP_068751
Function	Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. {ECO:0000250, ECO:0000269|PubMed:16629901}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RIC8A - MBS1269449 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC121808

RIC8A - MBS1276364 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC011821

Human RIC8A cDNA clone(NM_021932.4) - CDFG003446 from Creative Biomart Species Human Accession NM_021932.4

Human RIC8A ORF Clone(NM_021932.4) - CDCR307222 from Creative Biomart Species Human Accession NM_021932.4

Human RIC8A ORF Clone(NM_021932.4) - CDCR307223 from Creative Biomart Species Human Accession NM_021932.4

Human RIC8A ORF Clone(NM_021932.4) - CDCR307224 from Creative Biomart Species Human Accession NM_021932.4

Human RIC8A Gene ORF cDNA clone in cloning vector - HG15892-G from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15892-NF from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, N-His tag - HG15892-NH from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, C-His tag - HG15892-CH from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15892-ACR from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15892-CF from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, C-HA tag - HG15892-CY from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15892-CM from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid - HG15892-UT from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15892-NM from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15892-ACG from Sino Biological Species Human

Human RIC8A Gene ORF cDNA clone expression plasmid, N-HA tag - HG15892-NY from Sino Biological Species Human

human RIC8A ORF clone (NM_021932.4) - CDCH073868 from Creative biogene Species Human

Human RIC8A ORF Clone (BC011821) - CDCS415381 from Creative biogene Species Human Accession Q9NPQ8

Human RIC8A ORF Clone (BC121808) - CDCS415382 from Creative biogene Species Human Accession Q9NPQ8

Human RIC8A ORF clone (BC121808) - CDCB157687 from Creative biogene Species Human

Human RIC8A Gene cDNA Clone - orb145057 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human RIC8A cDNA Clone(NM_021932.4) - CDFG003446 from Creative biogene Species Human

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