RIC8A

Gene Symbol RIC8A
Entrez Gene 60626
Alt Symbol RIC8
Species Human
Gene Type protein-coding
Description RIC8 guanine nucleotide exchange factor A
Other Description resistance to inhibitors of cholinesterase 8 homolog A|synembryn-A
Swissprots Q9H5H3 Q9H064 Q7Z352 Q2T9J1 Q0P508 Q9H9E7 Q9NPQ8 Q96SZ2 Q96EZ1
Accessions CAE90494 EAW61244 EAW61245 EAW61246 Q9NPQ8 AK022870 BAB14282 AK026897 AK027090 BAB15653 AK027461 BAB55126 AK225420 AK314568 AL136935 CAB66869 AL390088 CAB98211 AM393435 CAL38313 BC011821 AAH11821 BC094717 BC111499 AAI11500 BC121807 AAI21808 BC121808 AAI21809 BX538115 CAD98025 XM_005253052 XP_005253109 XM_011520267 XP_011518569 XM_011520268 XP_011518570 XM_011520269 XP_011518571 XM_011520270 XP_011518572 XM_011520271 XP_011518573 XM_011520272 XP_011518574 NM_001286134 NP_001273063 NM_021932 NP_068751
Function Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. {ECO:0000250, ECO:0000269|PubMed:16629901}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

RIC-8A (C-3) - sc-398962 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RIC-8A (C-3): sc-398962. Western blot analysis of RIC-8A expression in HeLa (A), K-562 (B) and THP-1 (C) whole cell lysates.

RIC-8A (S-20) - sc-79034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RIC-8A (E-20) - sc-79033 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RIC8A antibody - ab194941 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RIC8A antibody (ab194941) at 0.1 µg/mlLane 1 : Whole cell lysate from HeLaLane 2 : Whole cell lysate from 293TLane 3 : Whole cell lysate from JurkatLane 4 : Whole cell lysate from TCMK-1Lane 5 : Whole cell lysate from NIH3T3Lysates/proteins at 50 µg per lane.

Anti-RIC8A antibody - ab97808 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RIC8A antibody (ab97808) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-RIC8A antibody - ab130616 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RIC8A antibody (ab130616) at 1/100 dilution + A2058 cell line lysate at 35 µg

Anti-RIC8A antibody [3G3] - ab118151 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G3
All lanes : Anti-RIC8A antibody [3G3] (ab118151) at 1/1000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY RIC8A cDNALysates/proteins at 5 µg per lane.

Anti-RIC8A Antibody (aa244-272, AP) - LS-C227012 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC8A Antibody (aa244-272, APC) - LS-C227013 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC8A Antibody (aa244-272, FITC) - LS-C227015 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC8A Antibody (aa244-272, Biotin) - LS-C227014 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC8A Antibody (aa244-272, Azide-free, HRP) - LS-C227016 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC8A Antibody (aa244-272, PE) - LS-C227017 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC8A Antibody (aa242-271) - LS-C324679 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIC8A Antibody (aa143-192) - LS-C116693 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RIC8A antibody LS-C116693 Western blot of THP-1 cell lysate.

Anti-RIC8A Antibody (aa244-272) - LS-C162603 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RIC8A Antibody western blot of A2058 cell line lysates (35 ug/lane). The RIC8A antibody detected the RIC8A protein (arrow).

Anti-RIC8A Antibody (aa528-537) - LS-C55395 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (1 ug/ml) of human brain lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-RIC8A Antibody (aa478-537) - LS-C185900 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Adrenal cortical tumor using RIC8A antibody at 1:100 dilution.

Anti-RIC8A Antibody (clone 3G3) - LS-C115097 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G3
IHC of paraffin-embedded Kidney tissue using anti-RIC8A mouse monoclonal antibody. (Dilution 1:50).

RIC8A Antibody (3G3) - NBP2-02433 from Novus Biologicals

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G3
Western Blot: RIC8 Antibody (3G3) [NBP2-02433] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RIC8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RIC8.

RIC8A Antibody - NBP1-57011 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RIC8 Antibody [NBP1-57011] - THP-1 cell lysate, concentration 0.2-1 ug/ml.

RIC8A Antibody - NBP2-36536 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RIC8A Antibody [NBP2-36536] - Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-Ric-8A antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

RIC8A Antibody - NB100-1473 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: RIC8A Antibody [NB100-1473] - Analysis of RIC8A in human brain lysate (RIPA buffer, 35ug total protein per lane) using this antibody at 1ug/ml. Primary incubated for 1 hour. Detected using chemiluminescence.

RIC8A Antibody - NBP2-36535 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RIC8A Antibody (1H6) - H00060626-M01-100ug from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H6
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