MTRR

Gene Symbol	MTRR
Entrez Gene	4552
Alt Symbol	MSR, cblE
Species	Human
Gene Type	protein-coding
Description	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Other Description	[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing)\|methionine synthase reductase\|methionine synthase reductase, mitochondrial
Swissprots	Q32MA9 Q9UBK8 Q7Z4M8 O60471
Accessions	AAF17303 AAF17304 EAX08090 EAX08091 EAX08092 EAX08093 Q9UBK8 AF025794 AAC39667 AF121214 AAF16876 AK308442 AK311663 BC035977 BC054816 AAH54816 BC062577 BC109216 AAI09217 BC109217 XM_006714474 XP_006714537 XM_011514043 XP_011512345 XM_011514044 XP_011512346 XM_011514045 XP_011512347 XR_241702 XR_241703 XR_925614 XR_925615 NM_002454 NP_002445 NM_024010 NP_076915
Function	Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. {ECO:0000269\|PubMed:17892308}.
Subcellular Location	Isoform A: Cytoplasm {ECO:0000269\|PubMed:18221906}.
Tissue Specificity	Found in all tissues tested, particularly abundant in skeletal muscle.

MSR (N-18) - sc-48889 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MSR (N-18): sc-48889. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic staining of glandular cells.

Anti-MTRR antibody - ab102567 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MTRR antibody (ab102567) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-MTRR antibody [EPR8349] - ab129159 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8349

All lanes : Anti-MTRR antibody [EPR8349] (ab129159) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : BxPC3 cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-MTRR Antibody (clone 1G7) - LS-C197717 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1G7

Anti-MTRR Antibody (Internal) - LS-C345682 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of MTRR Antibody with human HeLa Whole Cell lysate.

Anti-MTRR Antibody (aa71-120) - LS-C116725 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MTRR antibody LS-C116725 Western blot of HepG2 cell lysate.

Anti-MTRR Antibody (C-Terminus, clone EPR8349) - LS-C154441 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8349

Immunofluorescent staining of HeLa cells using anti-MTRR antibody.

MTRR Antibody - NBP1-57749 from Novus Biologicals

Prices	$369.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: MTRR Antibody [NBP1-57749] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

MTRR Antibody - NBP1-86596 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: MTRR Antibody [NBP1-86596] - staining of human skeletal muscle shows moderate cytoplasmic positivity in myocytes.

MTRR Antibody (1G7) - H00004552-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1G7

Anti-MTRR (91-105) antibody produced in rabbit - SAB1100145 from Sigma-Aldrich

Prices	$328.50
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti-MTRR (91-105), <B>Cat. No. SAB1100145</B>: Immunofluorescence of HUVEC cells using Anti-MTRR (91-105), SAB1100145 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Monoclonal Anti-MTRR antibody produced in mouse - WH0004552M1 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1G7

<B>Immunoblotting</B><BR/>Monoclonal Anti-MTRR, <B>Cat. No. WH0004552M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~38.21 kDa using immunogen protein lysate.

Anti-MTRR antibody produced in rabbit - HPA038113 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-MTRR: <B>Cat. No. HPA038113</B>: Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells of tubules.

MTRR antibody - N-terminal region (ARP57657_P050) - ARP57657_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MTRR Antibody - middle region (ARP74073_P050) - ARP74073_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MTRR antibody, N-term - GTX44879 from GeneTex

Prices	$319.00
Sizes	50 μg
Host	Rabbit
Clonality	Polyclonal

MTRR antibody - 70R-4020 from Fitzgerald

Prices	$345.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Macrophage Scavenger Receptor antibody - 20R-MG001 from Fitzgerald

Prices	$150.00, $625.00
Sizes	250 µl, 1 ml
Host	Goat
Clonality	Polyclonal

Methionine Synthase Reductase / MSR antibody - H00004552-A01 from Acris Antibodies

Prices	$300.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Methionine Synthase Reductase / MSR antibody - H00004552-M01 from Acris Antibodies

Prices	$360.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1G7

MTRR Antibody - GWB-MU914E from Genway Biotech

Prices	$368.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MTRR (aa 1-110) polyclonal antibody - DPAB-DC1968 from Creative Diagnostics

Host	Mouse
Clonality	Polyclonal

Methionine, Conjugated, Polyclonal Antibody - MBS6012115 from MyBioSource

Prices	$805.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-5-methyltetrahydrofolate-homocysteine methyltransferase reductase - 08A004552 from MP Biomedicals

Prices	$456.30
Sizes	100 μg
Host	Mouse
Clonality	Monoclonal
Clone	1G7

Anti-MTRR Antibody, clone EPR6110, rabbit monoclonal - MABN1086 from EMD Millipore

Host	Rabbit
Clonality	Monoclonal
Clone	EPR6110

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