RYBP

Gene Symbol RYBP
Entrez Gene 23429
Alt Symbol AAP1, DEDAF, YEAF1
Species Human
Gene Type protein-coding
Description RING1 and YY1 binding protein
Other Description APAP-1|DED-associated factor|RING1 and YY1-binding protein|YY1 and E4TF1 associated factor 1|YY1 and E4TF1-associated factor 1|apoptin-associating protein 1|death effector domain-associated factor|ring1 interactor RYBP
Swissprots Q9UMW4 Q9P2W5 Q8N488
Accessions CCQ43407 EAW65515 EAW65516 EAW65517 Q8N488 AB029551 BAA89486 AF085840 AF179286 AAD51858 AF227959 AAK63197 AL049940 AY228125 AAO73587 BC014959 AAH14959 BC036459 AAH36459 BF939411 DQ892214 ABM83140 DQ895410 ABM86336 XM_011548866 XP_011547168 XM_011548867 XP_011547169 NM_012234 NP_036366
Function Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis. {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711}.
Subcellular Location Nucleus. Cytoplasm. Nucleus, nucleoplasm {ECO:0000250}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in lymphoid tissues and placenta. {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135}.

RYBP (A-1) - sc-374235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RYBP (A-1): sc-374235. Western blot analysis of RYBP expression in K-562 whole cell lysate (A) and human placenta tissue extract (B).

RYBP (H-60) - sc-67058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RYBP (H-60): sc-67058. Western blot analysis of RYBP expression in non-transfected 293T: sc-117752 (A), human RYBP transfected 293T: sc-158945 (B) and K-562 (C) whole cell lysates.

RYBP (K-13) - sc-34929 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RYBP antibody - ab5976 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of DEDAF expression in human A549 (lane A), HepG2 (lane B), and mouse 3T3 (lane C) cell lysates withab5976 at 1 µg /ml.

Anti-RYBP antibody - ab107896 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RYBP antibody (ab107896) at 1 µg/mlLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 2 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell LysateLane 3 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell LysateLane 4 : JEG-3 (Human placental choriocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-RYBP antibody - ab2569 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RYBP antibody - ab129637 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RYBP antibody (ab129637) at 1/100 dilution + A375 cell line lysate at 35 µg

Anti-RYBP antibody - ab89603 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-RYBP antibody (ab89603) at 1 µg/ml + Human liver lysate at 50 µgdeveloped using the ECL technique

Anti-RYBP antibody [1B2] - ab128104 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B2
All lanes : Anti-RYBP antibody [1B2] (ab128104) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY RYBP cDNA Lysates/proteins at 5 µg per lane.

Anti-RYBP antibody [EPR13059(2)] - ab185971 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13059(2)
All lanes : Anti-RYBP antibody [EPR13059(2)] (ab185971) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : SW480 cell lysateLysates/proteins at 20 µg per lane.Secondarygoat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-RYBP Antibody (clone 1B2) - LS-C337716 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B2
IHC of paraffin-embedded Human pancreas tissue using anti-RYBP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-RYBP Antibody (aa215-228) - LS-C90340 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody - LS-C48308 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of RYBP antibody LS-C48308.

Anti-RYBP Antibody (aa56-105) - LS-C170158 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody (C-Terminus) - LS-C80245 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-RYBP Antibody (aa1-30, PE) - LS-C268685 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody (aa1-30, AP) - LS-C285192 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody (aa1-30, APC) - LS-C285193 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody (aa1-30, Biotin) - LS-C285194 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody (aa1-30, FITC) - LS-C285195 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody (aa1-30, Azide-free, HRP) - LS-C285199 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody (aa1-30) - LS-C324874 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RYBP Antibody (clone 5A9) - LS-C173904 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5A9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RYBP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RYBP.

Anti-RYBP Antibody (clone 2F6) - LS-C173902 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RYBP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RYBP.

Anti-RYBP Antibody (clone 7D1) - LS-C173903 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7D1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RYBP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RYBP.
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