| Gene Symbol |
RYBP
|
| Entrez Gene |
23429
|
| Alt Symbol |
AAP1, DEDAF, YEAF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RING1 and YY1 binding protein
|
| Other Description |
APAP-1|DED-associated factor|RING1 and YY1-binding protein|YY1 and E4TF1 associated factor 1|YY1 and E4TF1-associated factor 1|apoptin-associating protein 1|death effector domain-associated factor|ring1 interactor RYBP
|
| Swissprots |
Q9UMW4 Q9P2W5 Q8N488
|
| Accessions |
CCQ43407 EAW65515 EAW65516 EAW65517 Q8N488 AB029551 BAA89486 AF085840 AF179286 AAD51858 AF227959 AAK63197 AL049940 AY228125 AAO73587 BC014959 AAH14959 BC036459 AAH36459 BF939411 DQ892214 ABM83140 DQ895410 ABM86336 XM_011548866 XP_011547168 XM_011548867 XP_011547169 NM_012234 NP_036366
|
| Function |
Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis. {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Nucleus, nucleoplasm {ECO:0000250}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with highest levels in lymphoid tissues and placenta. {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135}.
|