Gene Symbol | RYBP |
---|---|
Entrez Gene | 23429 |
Alt Symbol | AAP1, DEDAF, YEAF1 |
Species | Human |
Gene Type | protein-coding |
Description | RING1 and YY1 binding protein |
Other Description | APAP-1|DED-associated factor|RING1 and YY1-binding protein|YY1 and E4TF1 associated factor 1|YY1 and E4TF1-associated factor 1|apoptin-associating protein 1|death effector domain-associated factor|ring1 interactor RYBP |
Swissprots | Q9UMW4 Q9P2W5 Q8N488 |
Accessions | CCQ43407 EAW65515 EAW65516 EAW65517 Q8N488 AB029551 BAA89486 AF085840 AF179286 AAD51858 AF227959 AAK63197 AL049940 AY228125 AAO73587 BC014959 AAH14959 BC036459 AAH36459 BF939411 DQ892214 ABM83140 DQ895410 ABM86336 XM_011548866 XP_011547168 XM_011548867 XP_011547169 NM_012234 NP_036366 |
Function | Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis. {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:19098711}. |
Subcellular Location | Nucleus. Cytoplasm. Nucleus, nucleoplasm {ECO:0000250}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250}. |
Tissue Specificity | Widely expressed with highest levels in lymphoid tissues and placenta. {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135}. |