| Gene Symbol |
PDK3
|
| Entrez Gene |
5165
|
| Alt Symbol |
CMTX6, GS1-358P8.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pyruvate dehydrogenase kinase, isozyme 3
|
| Other Description |
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 3|pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
|
| Swissprots |
Q15120 B4DXG6
|
| Accessions |
EAW99019 EAW99020 Q15120 AI001064 AI080664 AK301965 BAG63378 AW173304 BC015948 AAH15948 BC038512 BG717206 BI549903 BU069975 HG512466 L42452 AAC42011 NM_001142386 NP_001135858 NM_005391 NP_005382
|
| Function |
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.
|
| Subcellular Location |
Mitochondrion matrix.
|
| Tissue Specificity |
Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. {ECO:0000269|PubMed:23297365}.
|
![Western Blot: PDK3 Overexpression Lysate (Adult Normal) [NBL1-14251] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDK3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5151_PDK3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14251-img0002.jpg)