PDK3

Gene Symbol PDK3
Entrez Gene 5165
Alt Symbol CMTX6, GS1-358P8.4
Species Human
Gene Type protein-coding
Description pyruvate dehydrogenase kinase, isozyme 3
Other Description [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 3|pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
Swissprots Q15120 B4DXG6
Accessions EAW99019 EAW99020 Q15120 AI001064 AI080664 AK301965 BAG63378 AW173304 BC015948 AAH15948 BC038512 BG717206 BI549903 BU069975 HG512466 L42452 AAC42011 NM_001142386 NP_001135858 NM_005391 NP_005382
Function Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.
Subcellular Location Mitochondrion matrix.
Tissue Specificity Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. {ECO:0000269|PubMed:23297365}.

PDK3 (A-4) - sc-365378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDK3 (A-4): sc-365378. Western blot analysis of PDK3 expression in non-transfected: sc-117752 (A) and mouse PDK3 transfected: sc-122470 (B) 293T whole cell lysates.

PDK3 (A-16) - sc-14490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDK3 (A-16): sc-14490. Western blot analysis of PDK3 expression in non-transfected: sc-110760 (A) and human PDK3 transfected: sc-158838 (B) 293 whole cell lysates.

PDK3 (N-14) - sc-14488 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDK3 (N-14): sc-14488. Western blot analysis of PDK3 expression in non-transfected: sc-110760 (A) and human PDK3 transfected: sc-112250 (B) 293 whole cell lysates.

PDK3 (RR-2) - sc-100535 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PDK3 (RR-2): sc-100535. Western blot analysis of PDK3 expression in MCF7 whole cell lysate.

Anti-PDK3 antibody - ab154549 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PDK3 antibody (ab154549) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-PDK3 antibody - ab154558 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-PDK3 antibody (ab154558) at 1/5000 dilution + HepG2 whole cell lysate at 30 µg

Anti-PDK3 antibody - ab196286 from Abcam

Prices $370.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal
Immmunohistochemical analysis of formalin-fixed, paraffin-embedded Human fetal skeletal muscle tissue labeling PDK3 with ab196286 at 1/100 dilution.

Anti-PDK3 antibody - ab55579 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PDK3 antibody [EP12309] - ab182574 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP12309
Flow cytometric analysis of Raw26.7 cells (paraformaldehyde-fixed, 2%) labeling PDK3 with ab182574 at 1/400 dilution (red) or a rabbit IgG (negative) (green), followed by secondary Goat anti rabbit IgG (FITC) at 1/150 dilution. Isotype control Rabbit IgG.

Anti-PDK3 antibody - N-terminal - ab200091 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDK3 antibody - N-terminal (ab200091) at 1/1000 dilutionLane 1 : Mouse brain total cell extractsLane 2 : Mouse thymus total cell extracts

Anti-PDK3 Antibody (AP) - LS-C206853 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (Biotin) - LS-C206854 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (APC) - LS-C206855 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (C-Terminus) - LS-C111083 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PDK3 antibody LS-C111083 Western blot of OVCAR-3 cell lysate.

Anti-PDK3 Antibody (FITC) - LS-C206856 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (PE) - LS-C206858 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (aa74-123) - LS-C80835 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-PDK3 Antibody (aa387-414, AP) - LS-C207444 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (aa387-414, APC) - LS-C207445 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (aa387-414, Biotin) - LS-C207446 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (aa387-414, FITC) - LS-C207447 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody - LS-C158564 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
PDK3 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The PDK3 antibody detected the PDK3 protein (arrow).

Anti-PDK3 Antibody (aa387-414, Azide-free, HRP) - LS-C207448 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (aa387-414, PE) - LS-C207449 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDK3 Antibody (aa1-30, AP) - LS-C207450 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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