PDK3

Gene Symbol PDK3
Entrez Gene 5165
Alt Symbol CMTX6, GS1-358P8.4
Species Human
Gene Type protein-coding
Description pyruvate dehydrogenase kinase, isozyme 3
Other Description [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 3|pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
Swissprots Q15120 B4DXG6
Accessions EAW99019 EAW99020 Q15120 AI001064 AI080664 AK301965 BAG63378 AW173304 BC015948 AAH15948 BC038512 BG717206 BI549903 BU069975 HG512466 L42452 AAC42011 NM_001142386 NP_001135858 NM_005391 NP_005382
Function Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.
Subcellular Location Mitochondrion matrix.
Tissue Specificity Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. {ECO:0000269|PubMed:23297365}.

PDK3 CRISPR/Cas9 KO Plasmid (h) - sc-404502 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK3 HDR Plasmid (h) - sc-404502-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK3 Double Nickase Plasmid (h) - sc-404502-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK3 Double Nickase Plasmid (h2) - sc-404502-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK3 CRISPR Activation Plasmid (h) - sc-404502-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK3 CRISPR Activation Plasmid (h2) - sc-404502-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK3 Lentiviral Activation Particles (h) - sc-404502-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK3 Lentiviral Activation Particles (h2) - sc-404502-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK3 siRNA (h) - sc-39029 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDK3 shRNA Plasmid (h) - sc-39029-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDK3 shRNA (h) Lentiviral Particles - sc-39029-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDK3 RNAi - H00005165-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU048131 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1561 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1560 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1559 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN16567 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16567 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02954 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02954

PDK3 siRNA (Human) - CRH3445 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PDK3 (NM_005391.4) - SHH372888 from Creative biogene

Category siRNA
Species Reactivities Human

PDK3 shRNA Plasmid (Human) - CHH3445 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PDK3 miRNA 3'UTR clone - MiUTR3H-05062 from Creative biogene

Species Reactivities Human
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