PDK3

Gene Symbol	PDK3
Entrez Gene	5165
Alt Symbol	CMTX6, GS1-358P8.4
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 3
Other Description	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 3|pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
Swissprots	Q15120 B4DXG6
Accessions	EAW99019 EAW99020 Q15120 AI001064 AI080664 AK301965 BAG63378 AW173304 BC015948 AAH15948 BC038512 BG717206 BI549903 BU069975 HG512466 L42452 AAC42011 NM_001142386 NP_001135858 NM_005391 NP_005382
Function	Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.
Subcellular Location	Mitochondrion matrix.
Tissue Specificity	Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. {ECO:0000269|PubMed:23297365}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDK3 full length protein - ab125606 from Abcam Category Protein Prices $239.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Recombinant PDK3 (human), active - ab110355 from Abcam Source E. coli Species Human

PDK3 Antibody Blocking Peptide - LS-E3134 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK3 Antibody Blocking Peptide - LS-E16820 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK3 Antibody Blocking Peptide - LS-E8631 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PDK3 Protein - H00005165-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human PDK3 Protein - H00005165-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PDK3 Peptide - P2131 from Novus Biologicals Category Peptide Species Human

PDK3-Antibody-N-term-Blocking-Peptide - BP7040a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDK3 Blocking Peptide - 33R-8109 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDK3 Blocking Peptide - 33R-4222 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDK3 - H00005165-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

PDK3 - H00005165-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDK3 - H00005165-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDK3 - P5617 from Acris Antibodies Category Protein Prices $790.00 Sizes 5 µg Species Human

PDK3 fusion protein - Ag24597 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

PDK3 fusion protein - ag2879 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PDK3, His-tagged - PDK3-652H from Creative Biomart Category Protein Source Bacteria.

Recombinant Human PDK3, GST-tagged - PDK3-1072H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Pyruvate Dehydrogenase Kinase Isozyme 3 (PDK3) - RPD463Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitocho - CSB-YP613585HU CSB-EP613585HU CSB-BP613585HU CSB-MP613585HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PDK3 Protein - abx163456 from Abbexa Category Protein Species Human, Mouse, Rat

PDK3 (transcript variant 2) - TP302207 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PDK3 Recombinant Protein Antigen - NBP2-13745PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PDK3 Peptide, Human - M34GP11540H from Creative Peptides Category Peptide Source Synthetic. Species Human

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