| Gene Symbol |
SOX17
|
| Entrez Gene |
64321
|
| Alt Symbol |
VUR3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SRY (sex determining region Y)-box 17
|
| Other Description |
SRY-related HMG-box transcription factor SOX17|transcription factor SOX-17
|
| Swissprots |
Q9H6I2
|
| Accessions |
EAW86748 Q9H6I2 AB073988 BAB83867 AK025905 BAB15277 BC030209 AAH30209 BC111365 AAI11366 BC111770 AAI11771 BC140307 AAI40308 DA874945 NM_022454 NP_071899
|
| Function |
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}.
|
| Tissue Specificity |
Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum. {ECO:0000269|PubMed:11786926}.
|
| Top Pathways |
Wnt signaling pathway
|