SOX17

Gene Symbol SOX17
Entrez Gene 64321
Alt Symbol VUR3
Species Human
Gene Type protein-coding
Description SRY (sex determining region Y)-box 17
Other Description SRY-related HMG-box transcription factor SOX17|transcription factor SOX-17
Swissprots Q9H6I2
Accessions EAW86748 Q9H6I2 AB073988 BAB83867 AK025905 BAB15277 BC030209 AAH30209 BC111365 AAI11366 BC111770 AAI11771 BC140307 AAI40308 DA874945 NM_022454 NP_071899
Function Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}.
Tissue Specificity Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum. {ECO:0000269|PubMed:11786926}.
Top Pathways Wnt signaling pathway

Sox17 Antibody - 13963 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from OVCAR3 and SK-OV-3 cells using Sox17 Antibody.

Sox-17 (3.5CH) - sc-130295 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Sox-17 (3.5CH): sc-130295. Western blot analysis of Sox-17 expression in non-transfected: sc-110760 (A) and mouse Sox-17 transfected: sc-179488 (B) 293 whole cell lysates.

Sox-17 (H-130) - sc-20099 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Sox-17 (S-20) - sc-17355 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sox-17 (S-20): sc-17355. Western blot analysis of Sox-17 expression in mouse testis tissue extract.

Sox-17 (V-20) - sc-17356 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Sox-17 (V-20): sc-17356. Western blot analysis of Sox-17 expression in KNRK nuclear extract (A) and C6 whole cell lysate (B).

Anti-SOX17 [BC24-3.5CH] antibody - ab192453 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone BC24-3.5CH
Top image: Immunofluorescence staining of Rh18 and Rh30 Cells after treatment with Aphidicolin or Nocadazole labeling SOX17 using ab192453 and  PE anti-mouse Ig labeled secondary antibody.Bottom image: Immunofluorescence staining of TF1 hematopoietic stem cell line labeling SOX17 using ab192453 and TRITC labeled anti-mouse Ig secondary antibody.

Anti-SOX17 antibody - ab191699 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-SOX17 antibody (ab191699) at 0.5 µg/mlLane 2 : Anti-SOX17 antibody (ab191699) at 1 µg/mlLane 1 : HepG2 cell lysateLane 2 : HepG2 cell lysateLysates/proteins at 15 µg per lane.

Anti-SOX17 antibody - ab33101 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SOX17 antibody (ab33101) at 1 µg/ml + DU 145 (Human prostate carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-SOX17 antibody - ab83258 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Rabbit Anti-SOX17 Antibody ab83258. Paraffin Embedded Tissue: Human Kidney. Antibody Concentration: 5 ug/ml

Anti-SOX17 antibody - ab99370 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SOX17 antibody (ab99370) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Spleen (Human) Tissue Lysate - adult normal tissue (ab29699)Lane 3 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lane 4 : LNCaP human prostate carcinoma cell line lysate Whole Cell LysateLane 5 : PC3 (Human prostate carcinoma cell line) Whole Cell Lysate Whole Cell LysateLane 6 : DU 145 (Human prostate carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SOX17 antibody - ab155402 from Abcam

Prices $397.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SOX17 antibody (ab155402) at 1 µg/mlLane 1 : Mouse embryo brain lysateLane 2 : Mouse embryo brain lysate with immunizing peptideSecondaryGoat anti-rabbit Ig HRP developed using the ECL technique

Anti-SOX17 antibody [3B10] - ab84990 from Abcam

Prices $394.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B10
ab84990 staining SOX17 in the Human iPSC derived endoderm progenitor cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with 4% PFA, permeabilized with 0.1% Saponin buffer and blocked with 5% serum for 30 minutes at 20°C. Samples were incubated with 5µg/ml primary antibody in 0.1% Saponin buffer for 6 hours at 4°C. An Allophycocyanin-conjugated Goat anti-mouse IgG polyclonal (1/500) was used as the secondary antibody.See Abreview

Anti-SOX17 Antibody (aa338-348) - LS-C55517 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SOX17 Antibody (aa345-394) - LS-C29966 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal Lung Lysate

Anti-SOX17 Antibody (aa177-414, NL557) - LS-C126314 from LifeSpan Bioscience

Prices $605.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SOX17 Antibody (aa177-414, APC) - LS-C132164 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

Anti-SOX17 Antibody (Internal) - LS-C209991 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-SOX17 Antibody (clone 5G6F2) - LS-C114428 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G6F2
Anti-SOX17 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOX17.

Anti-SOX17 Antibody (aa120-170) - LS-C148617 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SOX17 in mouse embryo brain lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148617 at 2 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-SOX17 Antibody (aa376-409) - LS-C344641 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysates from LNCaP, mouse F9 cell line (from left to right) with Sox17 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20 ug per lane.

Anti-SOX17 Antibody (Internal) - LS-C336193 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of SOX17 in mouse liver tissue with SOX17 antibody at 20 ug/ml.

Anti-SOX17 Antibody (clone 3H5) - LS-C114341 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H5
Immunofluorescent staining of HeLa cells using anti-SOX17 mouse monoclonal antibody.

Anti-SOX17 Antibody (clone 2B6) - LS-C114427 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B6
IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-SOX17 mouse monoclonal antibody. (Dilution 1:50).

Anti-SOX17 Antibody (clone 2G8) - LS-C114375 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G8
Anti-SOX17 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SOX17.

Anti-SOX17 Antibody (C-Terminus) IHC-plus™ - LS-B3535 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SOX17 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3535 concentration 5 ug/ml.
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