SOX17

Gene Symbol SOX17
Entrez Gene 64321
Alt Symbol VUR3
Species Human
Gene Type protein-coding
Description SRY (sex determining region Y)-box 17
Other Description SRY-related HMG-box transcription factor SOX17|transcription factor SOX-17
Swissprots Q9H6I2
Accessions EAW86748 Q9H6I2 AB073988 BAB83867 AK025905 BAB15277 BC030209 AAH30209 BC111365 AAI11366 BC111770 AAI11771 BC140307 AAI40308 DA874945 NM_022454 NP_071899
Function Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267}.
Tissue Specificity Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum. {ECO:0000269|PubMed:11786926}.
Top Pathways Wnt signaling pathway

Sox-17 CRISPR/Cas9 KO Plasmid (h) - sc-401192 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 HDR Plasmid (h) - sc-401192-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 Double Nickase Plasmid (h) - sc-401192-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 Double Nickase Plasmid (h2) - sc-401192-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 CRISPR Activation Plasmid (h) - sc-401192-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 CRISPR Activation Plasmid (h2) - sc-401192-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 Lentiviral Activation Particles (h) - sc-401192-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 Lentiviral Activation Particles (h2) - sc-401192-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 siRNA (h) - sc-38429 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sox-17 shRNA Plasmid (h) - sc-38429-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sox-17 shRNA (h) Lentiviral Particles - sc-38429-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SOX17 RNAi - H00064321-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU049201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20353 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20353 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07281 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07281

SOX17 siRNA (Human) - CRJ1983 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOX17 - MBS829597 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Sox-17 CRISPR/Cas9 KO Plasmid (h2) - sc-401192-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Sox-17 HDR Plasmid (h2) - sc-401192-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SOX17 (NM_022454.3) - SHH415368 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SOX17(NM_022454.3) - SHL017238 from Creative biogene

Category siRNA
Species Reactivities Human

Human SOX17 siRNA - orb272484 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOX17 shRNA Plasmid (Human) - CHJ1983 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SOX17 miRNA 3'UTR clone - MiUTR1H-09764 from Creative biogene

Species Reactivities Human
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