| Gene Symbol |
PLXNA1
|
| Entrez Gene |
5361
|
| Alt Symbol |
NOV, NOVP, PLEXIN-A1, PLXN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin A1
|
| Other Description |
plexin 1|plexin-A1|semaphorin receptor NOV
|
| Swissprots |
Q9UIW2
|
| Accessions |
EAW79349 EAW79350 EAW79351 Q9UIW2 AI472001 AK054675 AK055605 AK126101 BAC86440 AK127254 AK128612 BAG54700 AK293425 BAG56931 AL136663 BC017323 BC032432 BC042904 BC156129 AAI56130 BC157020 AAI57021 BQ920360 X87832 CAB57274 XM_011512908 XP_011511210 XM_011512909 XP_011511211 NM_032242 NP_115618
|
| Function |
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected in fetal brain, lung, liver and kidney. {ECO:0000269|PubMed:8570614}.
|
| Top Pathways |
Axon guidance
|